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• W2034674953 abstract "Bacterial biofilms may be involved in refractory chronic rhinosinusitis (CRS). In vitro, we studied methods for removing biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa.Bacterial isolates were obtained from patients with refractory CRS and were plated and treated with either static administration of citric acid/zwitterionic surfactant (CAZS), saline delivered with hydrodynamic force, or CAZS delivered hydrodynamically. Results were assessed by counting colony-forming units (CFUs) and by confocal scanning laser microscopy (CSLM).All treatments produced significant reductions in CFU counts (p >or= 0.002). Hydrodynamic CAZS provided the greatest reduction, decreasing CFU counts from control values by 3.9 +/- 0.3 logs and 5.2 +/- 0.5 logs for S. aureus and P. aeruginosa, respectively (99.9% reduction; p = 0.001). CSLM showed decreases in biofilm coverage.Hydrodynamic delivery of a soap-like surfactant and a calcium-ion sequestering agent may disrupt biofilms associated with CRS. Our results may be relevant to a new approach to refractory CRS." @default.
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• W2034674953 date "2007-09-01" @default.
• W2034674953 modified "2023-10-14" @default.
• W2034674953 title "Methods for Removing Bacterial Biofilms: In Vitro Study using Clinical Chronic Rhinosinusitis Specimens" @default.
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• W2034674953 doi "https://doi.org/10.2500/ajr.2007.21.3069" @default.
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