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- W2034675462 abstract "Bacteria sequestered in a biofilm on medical implants appear to be much more recalcitrant toward antibiotic therapy than planktonic forms of the same bacteria. However, in vitro experiments show that application of ultrasound with antibiotic therapy increases the killing of the bacteria within the biofilm. Herein is reported the influence of ultrasonic power density and waveform in enhancing the action of the antibiotic against biofilms of Pseudomonas aeruginosa on a polyethylene substrate. Biofilm viability was measured after exposure to 12 μg ml−1 gentamicin sulfate and various intensities of 70 kHz continuous wave and pulsed insonation. The results indicate that cell death increases as the power density increases, and the amount of killing correlates with peak power density but not with average power density. These experiments were done at fairly low intensity (0.1 to 10 mW cm−2, spatial average temporal average), at which levels the ultrasound alone did not affect biofilm viability." @default.
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- W2034675462 date "1997-08-01" @default.
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- W2034675462 title "The role of insonation intensity in acoustic-enhanced antibiotic treatment of bacterial biofilms" @default.
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- W2034675462 doi "https://doi.org/10.1016/s0927-7765(97)00029-5" @default.
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