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• W2034676311 abstract "Due to the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The HIV-1 matrix (MA) protein is an essential viral component with established roles in the assembly of the virus. Using virtual and surface plasmon resonance (SPR)-based screening, we describe the identification of the first small molecule to bind to the HIV-1 MA protein and to possess broad range anti-HIV properties." @default.
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• W2034676311 date "2013-02-01" @default.
• W2034676311 modified "2023-09-23" @default.
• W2034676311 title "Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein" @default.
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• W2034676311 doi "https://doi.org/10.1016/j.bmcl.2012.11.041" @default.
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