Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034679346> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2034679346 endingPage "852" @default.
- W2034679346 startingPage "848" @default.
- W2034679346 abstract "Objectives. To identify the endogenous lectins of the human bladder with the long-term goal of developing improved strategies for the treatment of interstitial cystitis and other bladder disorders. Methods. Rabbit and human bladder sections were examined histochemically using biotinylated neoglycoconjugates. Affinity chromatography of extracts of rabbit bladder was performed on immobilized lactose to purify the galactose-binding protein. Results. Biotinylated beta-d-galactose neoglycoconjugate showed the strongest specific staining of the rabbit and human bladder sections. The beta-d-N-acetylglucosamine neoglycoconjugate also showed significant staining; the alpha-l-fucose, alpha-d-mannose, alpha-d-N-acetylneuraminic acid, and alpha-d-N-acetylgalactosamine neoglycoconjugates showed either very weak or no reaction. The strong Ca2+-independent binding of beta-d-galactose neoglycoconjugates suggested the presence of galectins in rabbit and human bladder. Affinity chromatography of rabbit bladder extract on lactose gel yielded a galectin of about 30 kDa, consistent with the molecular biological data confirming the expression of galectin-3 in bladder. Conclusions. Beta-d-galactose binds strongly and specifically to rabbit and human bladder tissue sections. This information would be useful for the purpose of modifying drugs used for the treatment of bladder disorders with ligands of galactose-binding lectins to improve their retention in the bladder." @default.
- W2034679346 created "2016-06-24" @default.
- W2034679346 creator A5062918646 @default.
- W2034679346 creator A5085129708 @default.
- W2034679346 date "1999-04-01" @default.
- W2034679346 modified "2023-10-18" @default.
- W2034679346 title "Endogenous carbohydrate-binding proteins of rabbit and human bladder" @default.
- W2034679346 cites W118551320 @default.
- W2034679346 cites W1498536727 @default.
- W2034679346 cites W1792792898 @default.
- W2034679346 cites W1970483521 @default.
- W2034679346 cites W1991402577 @default.
- W2034679346 cites W2038280143 @default.
- W2034679346 cites W2047395557 @default.
- W2034679346 cites W2053478651 @default.
- W2034679346 cites W2081240544 @default.
- W2034679346 cites W2133373983 @default.
- W2034679346 cites W2320950360 @default.
- W2034679346 cites W2334071755 @default.
- W2034679346 cites W4247644508 @default.
- W2034679346 doi "https://doi.org/10.1016/s0090-4295(98)00619-0" @default.
- W2034679346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10197873" @default.
- W2034679346 hasPublicationYear "1999" @default.
- W2034679346 type Work @default.
- W2034679346 sameAs 2034679346 @default.
- W2034679346 citedByCount "9" @default.
- W2034679346 crossrefType "journal-article" @default.
- W2034679346 hasAuthorship W2034679346A5062918646 @default.
- W2034679346 hasAuthorship W2034679346A5085129708 @default.
- W2034679346 hasConcept C126322002 @default.
- W2034679346 hasConcept C142724271 @default.
- W2034679346 hasConcept C153911025 @default.
- W2034679346 hasConcept C156293190 @default.
- W2034679346 hasConcept C185592680 @default.
- W2034679346 hasConcept C203014093 @default.
- W2034679346 hasConcept C204628709 @default.
- W2034679346 hasConcept C2776841590 @default.
- W2034679346 hasConcept C2778173381 @default.
- W2034679346 hasConcept C2778735756 @default.
- W2034679346 hasConcept C2779762690 @default.
- W2034679346 hasConcept C2780758401 @default.
- W2034679346 hasConcept C55493867 @default.
- W2034679346 hasConcept C71924100 @default.
- W2034679346 hasConcept C74864618 @default.
- W2034679346 hasConcept C86803240 @default.
- W2034679346 hasConceptScore W2034679346C126322002 @default.
- W2034679346 hasConceptScore W2034679346C142724271 @default.
- W2034679346 hasConceptScore W2034679346C153911025 @default.
- W2034679346 hasConceptScore W2034679346C156293190 @default.
- W2034679346 hasConceptScore W2034679346C185592680 @default.
- W2034679346 hasConceptScore W2034679346C203014093 @default.
- W2034679346 hasConceptScore W2034679346C204628709 @default.
- W2034679346 hasConceptScore W2034679346C2776841590 @default.
- W2034679346 hasConceptScore W2034679346C2778173381 @default.
- W2034679346 hasConceptScore W2034679346C2778735756 @default.
- W2034679346 hasConceptScore W2034679346C2779762690 @default.
- W2034679346 hasConceptScore W2034679346C2780758401 @default.
- W2034679346 hasConceptScore W2034679346C55493867 @default.
- W2034679346 hasConceptScore W2034679346C71924100 @default.
- W2034679346 hasConceptScore W2034679346C74864618 @default.
- W2034679346 hasConceptScore W2034679346C86803240 @default.
- W2034679346 hasIssue "4" @default.
- W2034679346 hasLocation W20346793461 @default.
- W2034679346 hasLocation W20346793462 @default.
- W2034679346 hasOpenAccess W2034679346 @default.
- W2034679346 hasPrimaryLocation W20346793461 @default.
- W2034679346 hasRelatedWork W2034679346 @default.
- W2034679346 hasRelatedWork W2045948777 @default.
- W2034679346 hasRelatedWork W2049833576 @default.
- W2034679346 hasRelatedWork W2074939791 @default.
- W2034679346 hasRelatedWork W2395192621 @default.
- W2034679346 hasRelatedWork W2398086286 @default.
- W2034679346 hasRelatedWork W2571062684 @default.
- W2034679346 hasRelatedWork W26449175 @default.
- W2034679346 hasRelatedWork W2749769927 @default.
- W2034679346 hasRelatedWork W4285166797 @default.
- W2034679346 hasVolume "53" @default.
- W2034679346 isParatext "false" @default.
- W2034679346 isRetracted "false" @default.
- W2034679346 magId "2034679346" @default.
- W2034679346 workType "article" @default.