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- W2034680068 abstract "The polar lipid fraction E (PLFE) isolated from the thermoacidophilic archaeon Sulfolobus acidocaldarius contains exclusively bipolar tetraether lipids, which are able to form extraordinarily stable vesicular membranes against a number of chemical, physical and mechanical stressors. In this study, we demonstrated that PLFE can also form free-standing “planar” membranes on micro-pores (∼100 micrometer) of polydimethylsiloxane (PDMS) thin films embedded in printed circuit board (PCB)-based fluidics. Using electrochemical impedance spectroscopy (EIS), we found that the dielectric properties of PLFE planar membranes suspended on the PDMS films are distinctly different from those obtained from diester lipid and triblock copolymer membranes. In addition to resistance (R) and capacitance (C) that were seen in all the membranes examined, PLFE planar membranes showed an inductance (L) component. Furthermore, PLFE planar membranes displayed a relatively large membrane resistance, suggesting that, among the membranes examined, PLFE planar membrane would be a better matrix for studying channel proteins and transmembrane events. PLFE planar membranes also exhibited a sharp decrease in phase angle with the frequency of the input AC signal at ∼1 MHz, which could be utilized to develop sensors for monitoring PLFE membrane integrity in fluidics. Since the stability of free-standing planar lipid membranes increases with increasing membrane packing tightness and PLFE lipid membranes are more tightly packed than those made of diester lipids, PLFE free-standing planar membranes are expected to be considerably stable. All these salient features make PLFE planar membranes particularly attractive for model studies of channel proteins and transmembrane events and for high-throughput drug screening." @default.
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- W2034680068 date "2015-01-01" @default.
- W2034680068 modified "2023-09-30" @default.
- W2034680068 title "Archaeal Tetraether Free Standing Lipid Membranes in a PDMS and PCB based Fluidic Platform" @default.
- W2034680068 doi "https://doi.org/10.1016/j.bpj.2014.11.2655" @default.
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