FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034680147> ?p ?o ?g. }

• W2034680147 endingPage "66" @default.
• W2034680147 startingPage "59" @default.
• W2034680147 abstract "Nitric oxide (NO) has been pointed out as being the main mediator involved in the hypotension and tissue injury taking place during sepsis. This study aimed to investigate the cellular mechanisms implicated in the acetylcholine (ACh)-induced relaxation detected in aortic rings isolated from rats submitted to cecal ligation and perforation (CLP group), 6 h post-CLP. The mean arterial pressure was recorded, and the concentration-effect curves for ACh were constructed for endothelium-intact aortic rings in the absence (control) or after incubation with one of the following NO synthase inhibitors: L-NAME (non-selective), L-NNA (more selective for eNOS), 7-nitroindazole (more selective for nNOS), or 1400 W (selective for iNOS). The NO concentration was determined by using confocal microscopy. The protein expression of the NOS isoforms was quantified by Western blot analysis. The prostacyclin concentration was indirectly analyzed on the basis of 6-keto-prostaglandin F1α (6-keto-PGF1α) levels measured by enzyme immunoassay. There were no differences between Sham- and CLP-operated rats in terms of the relaxation induced by acetylcholine. However, the NOS inhibitors reduced this relaxation in both groups, but this effect remained more pronounced in the CLP group as compared to the Sham group. The acetylcholine-induced NO production was higher in the rat aortic endothelial cells of the CLP group than in those of the Sham group. eNOS protein expression was larger in the CLP group, but the iNOS protein was not verified in any of the groups. The basal 6-keto-PGF1α levels were higher in the CLP group, but the acetylcholine-stimulated levels did not increase in CLP as much as they did in the Sham group. Taken together, our results show that the augmented NO production in sepsis syndrome elicited by cecal ligation and perforation is due to eNOS up-regulation and not to iNOS." @default.
• W2034680147 created "2016-06-24" @default.
• W2034680147 creator A5024163727 @default.
• W2034680147 creator A5033343978 @default.
• W2034680147 creator A5039162834 @default.
• W2034680147 creator A5055645149 @default.
• W2034680147 creator A5056776784 @default.
• W2034680147 creator A5058542772 @default.
• W2034680147 creator A5058788504 @default.
• W2034680147 date "2012-06-01" @default.
• W2034680147 modified "2023-09-27" @default.
• W2034680147 title "Augmented nitric oxide production and up-regulation of endothelial nitric oxide synthase during cecal ligation and perforation" @default.
• W2034680147 cites W1770431655 @default.
• W2034680147 cites W1851149345 @default.
• W2034680147 cites W1858880537 @default.
• W2034680147 cites W1971737748 @default.
• W2034680147 cites W1972836643 @default.
• W2034680147 cites W1977662482 @default.
• W2034680147 cites W1979994394 @default.
• W2034680147 cites W1986238277 @default.
• W2034680147 cites W1988293639 @default.
• W2034680147 cites W1988303740 @default.
• W2034680147 cites W2000886554 @default.
• W2034680147 cites W2016408832 @default.
• W2034680147 cites W2018424479 @default.
• W2034680147 cites W2021992999 @default.
• W2034680147 cites W2023170094 @default.
• W2034680147 cites W2025623288 @default.
• W2034680147 cites W2039406268 @default.
• W2034680147 cites W2042277367 @default.
• W2034680147 cites W2044261371 @default.
• W2034680147 cites W2052391094 @default.
• W2034680147 cites W2060902559 @default.
• W2034680147 cites W2070564305 @default.
• W2034680147 cites W2079465040 @default.
• W2034680147 cites W2085430726 @default.
• W2034680147 cites W2094022424 @default.
• W2034680147 cites W2103017013 @default.
• W2034680147 cites W2115717416 @default.
• W2034680147 cites W2118735797 @default.
• W2034680147 cites W2131036346 @default.
• W2034680147 cites W2144109738 @default.
• W2034680147 cites W2145570729 @default.
• W2034680147 cites W2160277272 @default.
• W2034680147 cites W2161900747 @default.
• W2034680147 cites W2165791807 @default.
• W2034680147 cites W2334629896 @default.
• W2034680147 cites W2404742918 @default.
• W2034680147 cites W2768146862 @default.
• W2034680147 cites W346538768 @default.
• W2034680147 cites W4293247451 @default.
• W2034680147 cites W4313343413 @default.
• W2034680147 cites W4324277493 @default.
• W2034680147 doi "https://doi.org/10.1016/j.niox.2012.04.005" @default.
• W2034680147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22561111" @default.
• W2034680147 hasPublicationYear "2012" @default.
• W2034680147 type Work @default.
• W2034680147 sameAs 2034680147 @default.
• W2034680147 citedByCount "14" @default.
• W2034680147 countsByYear W20346801472012 @default.
• W2034680147 countsByYear W20346801472013 @default.
• W2034680147 countsByYear W20346801472014 @default.
• W2034680147 countsByYear W20346801472015 @default.
• W2034680147 countsByYear W20346801472016 @default.
• W2034680147 countsByYear W20346801472019 @default.
• W2034680147 countsByYear W20346801472020 @default.
• W2034680147 countsByYear W20346801472021 @default.
• W2034680147 crossrefType "journal-article" @default.
• W2034680147 hasAuthorship W2034680147A5024163727 @default.
• W2034680147 hasAuthorship W2034680147A5033343978 @default.
• W2034680147 hasAuthorship W2034680147A5039162834 @default.
• W2034680147 hasAuthorship W2034680147A5055645149 @default.
• W2034680147 hasAuthorship W2034680147A5056776784 @default.
• W2034680147 hasAuthorship W2034680147A5058542772 @default.
• W2034680147 hasAuthorship W2034680147A5058788504 @default.
• W2034680147 hasConcept C104317684 @default.
• W2034680147 hasConcept C126322002 @default.
• W2034680147 hasConcept C134018914 @default.
• W2034680147 hasConcept C179437574 @default.
• W2034680147 hasConcept C185592680 @default.
• W2034680147 hasConcept C191897082 @default.
• W2034680147 hasConcept C192562407 @default.
• W2034680147 hasConcept C2775910092 @default.
• W2034680147 hasConcept C2776415932 @default.
• W2034680147 hasConcept C2776992346 @default.
• W2034680147 hasConcept C2777622882 @default.
• W2034680147 hasConcept C2778326061 @default.
• W2034680147 hasConcept C2778456384 @default.
• W2034680147 hasConcept C2778527123 @default.
• W2034680147 hasConcept C2780664492 @default.
• W2034680147 hasConcept C2781128415 @default.
• W2034680147 hasConcept C2908688039 @default.
• W2034680147 hasConcept C519581460 @default.
• W2034680147 hasConcept C55493867 @default.
• W2034680147 hasConcept C71924100 @default.
• W2034680147 hasConceptScore W2034680147C104317684 @default.
• W2034680147 hasConceptScore W2034680147C126322002 @default.
• W2034680147 hasConceptScore W2034680147C134018914 @default.

• next