Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034681143> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2034681143 endingPage "494" @default.
- W2034681143 startingPage "486" @default.
- W2034681143 abstract "CH330331 is a prototype of a new class of synthetic small molecule tyrosine kinase inhibitors (TKIs). In vitro Caco-2 cell monolayers, the in situ single-pass rat intestinal perfusion (SPIP) technique with mesenteric vein cannulated and an in vivo animal model were employed to investigate its permeability and transepithelial transport mechanisms. The Caco-2 model showed that the transport of CH330331 across the monolayers from the apical (AP) to basolateral (BL) side was 6- to 10-fold higher than that from the BL to AP side. The apparent permeability coefficient (P(app) ) values of CH330331 at 5-20 µg/ml from the AP to BL and from BL to AP side were 5.30-2.21 × 10(-6) cm/s, with a decrease in P(app) values from the AP to BL side at increased CH330331 concentrations. In the perfused rat intestinal model, a concentration dependent change in permeability was detected where P(blood) at 5 µg/ml (1.66 ± 0.69 × 10(-6) cm/s) and 10 µg/ml (1.80 ± 0.45 × 10(-6) cm/s) was significantly different from P(blood) at 20 µg/ml (0.98 ± 0.31 × 10(-6) cm/s, p<0.05). Some inhibitors could also change the transepithelial transport of CH330331. Moreover, the in vivo study showed that the oral bioavailability of CH330331 was 82.7% in the rat. All the results confirmed that the transepithelial transport of CH330331 was rapid and saturable, which might involve an active mechanism. The oral bioavailability of CH330331 was relatively high in vivo." @default.
- W2034681143 created "2016-06-24" @default.
- W2034681143 creator A5020183416 @default.
- W2034681143 creator A5027649946 @default.
- W2034681143 creator A5054678274 @default.
- W2034681143 creator A5056036725 @default.
- W2034681143 creator A5059829036 @default.
- W2034681143 date "2010-10-08" @default.
- W2034681143 modified "2023-10-15" @default.
- W2034681143 title "Absorption of CH330331, a novel 4-anilinoquinazoline inhibitor of epidermal growth factor receptor tyrosine kinase: comparative studies using in vitro, in situ and in vivo models" @default.
- W2034681143 cites W1574019439 @default.
- W2034681143 cites W1628890212 @default.
- W2034681143 cites W1970361311 @default.
- W2034681143 cites W1979196526 @default.
- W2034681143 cites W1981078630 @default.
- W2034681143 cites W1984226397 @default.
- W2034681143 cites W2009952106 @default.
- W2034681143 cites W2018388482 @default.
- W2034681143 cites W2042096520 @default.
- W2034681143 cites W2045156702 @default.
- W2034681143 cites W2059843617 @default.
- W2034681143 cites W2061155379 @default.
- W2034681143 cites W2064388529 @default.
- W2034681143 cites W2073909305 @default.
- W2034681143 cites W2076633860 @default.
- W2034681143 cites W2076993862 @default.
- W2034681143 cites W2099895086 @default.
- W2034681143 cites W2110012018 @default.
- W2034681143 cites W2135117965 @default.
- W2034681143 cites W2161541244 @default.
- W2034681143 cites W2167368130 @default.
- W2034681143 cites W2168858467 @default.
- W2034681143 doi "https://doi.org/10.1002/bdd.729" @default.
- W2034681143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20936649" @default.
- W2034681143 hasPublicationYear "2010" @default.
- W2034681143 type Work @default.
- W2034681143 sameAs 2034681143 @default.
- W2034681143 citedByCount "0" @default.
- W2034681143 crossrefType "journal-article" @default.
- W2034681143 hasAuthorship W2034681143A5020183416 @default.
- W2034681143 hasAuthorship W2034681143A5027649946 @default.
- W2034681143 hasAuthorship W2034681143A5054678274 @default.
- W2034681143 hasAuthorship W2034681143A5056036725 @default.
- W2034681143 hasAuthorship W2034681143A5059829036 @default.
- W2034681143 hasConcept C121608353 @default.
- W2034681143 hasConcept C126322002 @default.
- W2034681143 hasConcept C150903083 @default.
- W2034681143 hasConcept C170493617 @default.
- W2034681143 hasConcept C181389837 @default.
- W2034681143 hasConcept C185592680 @default.
- W2034681143 hasConcept C193176779 @default.
- W2034681143 hasConcept C202751555 @default.
- W2034681143 hasConcept C207001950 @default.
- W2034681143 hasConcept C2778820342 @default.
- W2034681143 hasConcept C2781071285 @default.
- W2034681143 hasConcept C42362537 @default.
- W2034681143 hasConcept C55493867 @default.
- W2034681143 hasConcept C71924100 @default.
- W2034681143 hasConcept C86803240 @default.
- W2034681143 hasConcept C98274493 @default.
- W2034681143 hasConceptScore W2034681143C121608353 @default.
- W2034681143 hasConceptScore W2034681143C126322002 @default.
- W2034681143 hasConceptScore W2034681143C150903083 @default.
- W2034681143 hasConceptScore W2034681143C170493617 @default.
- W2034681143 hasConceptScore W2034681143C181389837 @default.
- W2034681143 hasConceptScore W2034681143C185592680 @default.
- W2034681143 hasConceptScore W2034681143C193176779 @default.
- W2034681143 hasConceptScore W2034681143C202751555 @default.
- W2034681143 hasConceptScore W2034681143C207001950 @default.
- W2034681143 hasConceptScore W2034681143C2778820342 @default.
- W2034681143 hasConceptScore W2034681143C2781071285 @default.
- W2034681143 hasConceptScore W2034681143C42362537 @default.
- W2034681143 hasConceptScore W2034681143C55493867 @default.
- W2034681143 hasConceptScore W2034681143C71924100 @default.
- W2034681143 hasConceptScore W2034681143C86803240 @default.
- W2034681143 hasConceptScore W2034681143C98274493 @default.
- W2034681143 hasIssue "8-9" @default.
- W2034681143 hasLocation W20346811431 @default.
- W2034681143 hasLocation W20346811432 @default.
- W2034681143 hasOpenAccess W2034681143 @default.
- W2034681143 hasPrimaryLocation W20346811431 @default.
- W2034681143 hasRelatedWork W1887906482 @default.
- W2034681143 hasRelatedWork W1897726688 @default.
- W2034681143 hasRelatedWork W1965016416 @default.
- W2034681143 hasRelatedWork W1983855168 @default.
- W2034681143 hasRelatedWork W2139434527 @default.
- W2034681143 hasRelatedWork W2379311614 @default.
- W2034681143 hasRelatedWork W2614005562 @default.
- W2034681143 hasRelatedWork W2753834235 @default.
- W2034681143 hasRelatedWork W2906638513 @default.
- W2034681143 hasRelatedWork W3109196503 @default.
- W2034681143 hasVolume "31" @default.
- W2034681143 isParatext "false" @default.
- W2034681143 isRetracted "false" @default.
- W2034681143 magId "2034681143" @default.
- W2034681143 workType "article" @default.