FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034681251> ?p ?o ?g. }

• W2034681251 endingPage "252" @default.
• W2034681251 startingPage "241" @default.
• W2034681251 abstract "The postnatal developmental expression of somatostatin mRNA and peptide in the rat hypoglossal nucleus was analyzed using immunocytochemical and in situ hybridization techniques. Both the neuropeptide and its cognate mRNA were found to be transiently present within a subpopulation of hypoglossal motoneurons during the neonatal period. At the day of birth, a large population of perikarya situated in caudal, ventral regions of the hypoglossal nucleus expressed somatostatin. By postnatal day 7, the number of hypoglossal somata which expressed somatostatin had diminished considerably, and by 2 weeks postnatal, only few such cell bodies were found. By 3–4 weeks postnatal, somatostatin peptide- and mRNA-containing hypoglossal motoneurons were rarely observed, and in the adult, they were never detected, despite the use of colchicine. A double-labeling co-localization technique was used to demonstrate that somatostatin, when present perinatally, always coexisted with calcitonin gene-related peptide in hypoglossal motoneurons. The latter peptide, in contrast to somatostatin, was expressed in large numbers of somata throughout the entire hypoglossal nucleus and persisted within the motoneurons throughout development into adulthood. These results demonstrate that somatostatin is transiently expressed in motoneurons of the caudal, ventral tier of the hypoglossal nucleus in the neonatal rat. The developmental disappearance of somatostatin is most likely not due to cell death; hypoglossal somata continue to express calcitonin gene-related peptide, with which somatostatin coexisted perinatally, at high levels throughout development. Thus, it appears that the regulation of somatostatin in expression in hypoglossal neurons occurs at the level of gene transcription or mRNA stability/degradation. The restricted temporal and spatial distribution suggests that somatostatin may have a role in some developmental aspect of a population of hypoglossal motoneurons which function to protrude the tongue." @default.
• W2034681251 created "2016-06-24" @default.
• W2034681251 creator A5002013152 @default.
• W2034681251 creator A5010840211 @default.
• W2034681251 creator A5047439852 @default.
• W2034681251 creator A5071976003 @default.
• W2034681251 creator A5077494149 @default.
• W2034681251 date "1991-06-01" @default.
• W2034681251 modified "2023-10-01" @default.
• W2034681251 title "Transient expression of somatostatin messenger RNA and peptide in the hypoglossal nucleus of the neonatal rat" @default.
• W2034681251 cites W1591414872 @default.
• W2034681251 cites W1594972985 @default.
• W2034681251 cites W1966074450 @default.
• W2034681251 cites W1968616820 @default.
• W2034681251 cites W1971401160 @default.
• W2034681251 cites W1973488253 @default.
• W2034681251 cites W1979566783 @default.
• W2034681251 cites W1984046067 @default.
• W2034681251 cites W1984524939 @default.
• W2034681251 cites W1985487450 @default.
• W2034681251 cites W1985884657 @default.
• W2034681251 cites W1986647797 @default.
• W2034681251 cites W1989596698 @default.
• W2034681251 cites W1991637403 @default.
• W2034681251 cites W1993636167 @default.
• W2034681251 cites W1993902481 @default.
• W2034681251 cites W1994718527 @default.
• W2034681251 cites W1996272241 @default.
• W2034681251 cites W1996582489 @default.
• W2034681251 cites W1996748400 @default.
• W2034681251 cites W1998874351 @default.
• W2034681251 cites W2001220158 @default.
• W2034681251 cites W2001280030 @default.
• W2034681251 cites W2003173108 @default.
• W2034681251 cites W2005044527 @default.
• W2034681251 cites W2006849654 @default.
• W2034681251 cites W2007567221 @default.
• W2034681251 cites W2009205613 @default.
• W2034681251 cites W2015651390 @default.
• W2034681251 cites W2016911571 @default.
• W2034681251 cites W2019224452 @default.
• W2034681251 cites W2019891842 @default.
• W2034681251 cites W2026345797 @default.
• W2034681251 cites W2027743126 @default.
• W2034681251 cites W2030546931 @default.
• W2034681251 cites W2033489013 @default.
• W2034681251 cites W2033983055 @default.
• W2034681251 cites W2041759487 @default.
• W2034681251 cites W2042139818 @default.
• W2034681251 cites W2045313047 @default.
• W2034681251 cites W2049784040 @default.
• W2034681251 cites W2049993885 @default.
• W2034681251 cites W2054170087 @default.
• W2034681251 cites W2055028997 @default.
• W2034681251 cites W2055674702 @default.
• W2034681251 cites W2056774661 @default.
• W2034681251 cites W2058779016 @default.
• W2034681251 cites W2059819806 @default.
• W2034681251 cites W2060183661 @default.
• W2034681251 cites W2065948718 @default.
• W2034681251 cites W2066184666 @default.
• W2034681251 cites W2068806168 @default.
• W2034681251 cites W2069532486 @default.
• W2034681251 cites W2071185127 @default.
• W2034681251 cites W2074487245 @default.
• W2034681251 cites W2076279547 @default.
• W2034681251 cites W2078059378 @default.
• W2034681251 cites W2079502761 @default.
• W2034681251 cites W2079837275 @default.
• W2034681251 cites W2081625123 @default.
• W2034681251 cites W2082996866 @default.
• W2034681251 cites W2083768175 @default.
• W2034681251 cites W2088378413 @default.
• W2034681251 cites W2092819442 @default.
• W2034681251 cites W2095261333 @default.
• W2034681251 cites W2104899731 @default.
• W2034681251 cites W2111344548 @default.
• W2034681251 cites W2142910727 @default.
• W2034681251 cites W2145641536 @default.
• W2034681251 cites W2152848856 @default.
• W2034681251 cites W2413136139 @default.
• W2034681251 cites W2885298878 @default.
• W2034681251 cites W4243400726 @default.
• W2034681251 doi "https://doi.org/10.1016/0165-3806(91)90053-l" @default.
• W2034681251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1680035" @default.
• W2034681251 hasPublicationYear "1991" @default.
• W2034681251 type Work @default.
• W2034681251 sameAs 2034681251 @default.
• W2034681251 citedByCount "19" @default.
• W2034681251 crossrefType "journal-article" @default.
• W2034681251 hasAuthorship W2034681251A5002013152 @default.
• W2034681251 hasAuthorship W2034681251A5010840211 @default.
• W2034681251 hasAuthorship W2034681251A5047439852 @default.
• W2034681251 hasAuthorship W2034681251A5071976003 @default.
• W2034681251 hasAuthorship W2034681251A5077494149 @default.
• W2034681251 hasConcept C104317684 @default.
• W2034681251 hasConcept C105580179 @default.
• W2034681251 hasConcept C118303440 @default.

• next