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• W2034681429 abstract "To clarify whether the increase in estrogen levels occurring during twin pregnancies (TP) is associated with a greater risk of developing intrahepatic cholestasis of pregnancy (ICP), we followed up 62 consecutive patients with TP and compared them with single pregnancies delivered in our hospital during 1 year. The prevalence of ICP was significantly higher in twin than in single pregnancies (20.9% versus 4.7%, respectively; P less than 0.001). Urinary estriol excretion was also significantly higher in twin compared to single pregnancies, although no quantitative differences were detected in TP with or without ICP. In multiparous patients with a proband TP affected by ICP, the disease recurred only in further TP, emphasizing the important role that estrogens seem to play in the pathogenesis of ICP. In contrast, in multiparous patients with a proband single pregnancy affected by ICP, the disease occurred in 70.5% of their other single pregnancies, suggesting the presence of a metabolic predisposition in these cases. However, in both groups of multiparous women a notable number of single pregnancies were not affected by the disease, supporting the postulate that the pathogenesis of ICP is multifactorial and that some as yet unidentified environmental factor needs to be present in order to develop the disease and also to modulate its expressivity." @default.
• W2034681429 created "2016-06-24" @default.
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• W2034681429 date "1989-07-01" @default.
• W2034681429 modified "2023-10-14" @default.
• W2034681429 title "Intrahepatic cholestasis of pregnancy in twin pregnancies" @default.
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• W2034681429 doi "https://doi.org/10.1016/0168-8278(89)90079-2" @default.
• W2034681429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2768798" @default.
• W2034681429 hasPublicationYear "1989" @default.
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