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• W2034683076 abstract "Tumor protein D52 is expressed at high levels in exocrine cells containing large secretory granules where it regulates Ca2+-dependent protein secretion; however, D52 expression is also highly induced in multiple cancers. The present study investigated a role for the Ca2+-dependent phosphorylation of D52 at the single major phospho-acceptor site serine 136 on cell division. Ectopic expression of wild type D52 (D52wt) and the phosphomutants serine 136/alanine (S136A) or serine 136/glutamate (S136/E) resulted in significant multinucleation of cells. D52wt and S136/E each resulted in a greater than 2-fold increase in multinucleated cells compared to plasmid-transfected controls whereas the S136/A phospho-null mutant caused a 9-fold increase in multinucleation at 48 h post-transfection. Electron microscopy revealed D52 expression induced a marked accumulation of vesicles along the mid-line between nuclei where the final stages of cell abscission normally occurs. Supporting this, D52wt strongly colocalized on vesicular structures containing the endosomal regulatory protein vesicle associated membrane protein 8 (VAMP 8) and this colocalization significantly increased with elevations in cellular Ca2+. As VAMP 8 is known to be necessary for the endo-membrane fusion reactions that mediate the final stages of cytokinesis, these data indicate that D52 expression and phosphorylation at serine 136 play an important role in supporting the Ca2+-dependent membrane trafficking events necessary for cytokinesis in rapidly proliferating cancer cells." @default.
• W2034683076 created "2016-06-24" @default.
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• W2034683076 date "2010-11-01" @default.
• W2034683076 modified "2023-10-01" @default.
• W2034683076 title "A role for tumor protein TPD52 phosphorylation in endo-membrane trafficking during cytokinesis" @default.
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• W2034683076 doi "https://doi.org/10.1016/j.bbrc.2010.10.041" @default.
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