Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034683602> ?p ?o ?g. }
- W2034683602 endingPage "353" @default.
- W2034683602 startingPage "345" @default.
- W2034683602 abstract "Purpose of review Highly selected, long-surviving, liver allograft recipients with normal/near normal liver injury tests can be weaned from immunosuppression. Baseline biopsies document changes before weaning and can help stratify risk of rejection or dysfunction after weaning; biopsies after weaning are used to study mechanisms of operational tolerance and to monitor for subclinical events. Recent findings Clinicopathological features associated with successful weaning include a lack of sensitization [negative donor-specific antibodies (DSA) and lack of tissue C4d deposits]; ‘inexperienced’ recipient immune system with limited potential for cross-reactivity (less immunological memory; infant recipients); noninflamed allograft in those with nonviral, nonimmunological original diseases; upregulation of liver genes associated with iron metabolism; allograft colonization with ‘immunosuppressive’ cells (Treg and γδ-1 >γδ-2); and longer time on immunosuppression, which might signal slow clonal deletion or silencing. The differential diagnosis of histopathological findings detected before and after weaning includes emerging infections, typical and atypical cellular rejection, indolent antibody-mediated rejection, ‘autoimmunity’, and other causes of progressive fibrosis. Summary Operationally tolerant liver allograft recipients can be successfully managed with very low, and sometimes no immunosuppression, but challenges exist. Newer approaches to tissue pathology and tissue, serum, and cross-platform analytics are needed to predict successful weaning and to monitor for subclinical events." @default.
- W2034683602 created "2016-06-24" @default.
- W2034683602 creator A5024291093 @default.
- W2034683602 creator A5052520143 @default.
- W2034683602 date "2013-06-01" @default.
- W2034683602 modified "2023-10-17" @default.
- W2034683602 title "Tissue biopsy monitoring of operational tolerance in liver allograft recipients" @default.
- W2034683602 cites W1503513950 @default.
- W2034683602 cites W1523201746 @default.
- W2034683602 cites W1560884792 @default.
- W2034683602 cites W1650494950 @default.
- W2034683602 cites W1955591537 @default.
- W2034683602 cites W1963903091 @default.
- W2034683602 cites W1966198810 @default.
- W2034683602 cites W1967582887 @default.
- W2034683602 cites W1968126941 @default.
- W2034683602 cites W1968927137 @default.
- W2034683602 cites W1969251068 @default.
- W2034683602 cites W1969893909 @default.
- W2034683602 cites W1979833056 @default.
- W2034683602 cites W1983211338 @default.
- W2034683602 cites W1985472464 @default.
- W2034683602 cites W1986865121 @default.
- W2034683602 cites W1993669291 @default.
- W2034683602 cites W1994927889 @default.
- W2034683602 cites W1997588364 @default.
- W2034683602 cites W1998464796 @default.
- W2034683602 cites W2001058947 @default.
- W2034683602 cites W2005394280 @default.
- W2034683602 cites W2005885579 @default.
- W2034683602 cites W2007129827 @default.
- W2034683602 cites W2009310930 @default.
- W2034683602 cites W2011711141 @default.
- W2034683602 cites W2012382212 @default.
- W2034683602 cites W2017566309 @default.
- W2034683602 cites W2027587297 @default.
- W2034683602 cites W2030010599 @default.
- W2034683602 cites W2031820291 @default.
- W2034683602 cites W2033904059 @default.
- W2034683602 cites W2034597199 @default.
- W2034683602 cites W2037999444 @default.
- W2034683602 cites W2040532261 @default.
- W2034683602 cites W2042775052 @default.
- W2034683602 cites W2043400916 @default.
- W2034683602 cites W2045108577 @default.
- W2034683602 cites W2046236804 @default.
- W2034683602 cites W2047921969 @default.
- W2034683602 cites W2049950882 @default.
- W2034683602 cites W2055987727 @default.
- W2034683602 cites W2058311698 @default.
- W2034683602 cites W2060676541 @default.
- W2034683602 cites W2061253187 @default.
- W2034683602 cites W2063601781 @default.
- W2034683602 cites W2064323880 @default.
- W2034683602 cites W2064614264 @default.
- W2034683602 cites W2066785962 @default.
- W2034683602 cites W2074145373 @default.
- W2034683602 cites W2080672488 @default.
- W2034683602 cites W2081006343 @default.
- W2034683602 cites W2082606641 @default.
- W2034683602 cites W2082830782 @default.
- W2034683602 cites W2087216431 @default.
- W2034683602 cites W2091489376 @default.
- W2034683602 cites W2097192629 @default.
- W2034683602 cites W2099290339 @default.
- W2034683602 cites W2101435342 @default.
- W2034683602 cites W2107649968 @default.
- W2034683602 cites W2111464175 @default.
- W2034683602 cites W2117006013 @default.
- W2034683602 cites W2117600377 @default.
- W2034683602 cites W2117821771 @default.
- W2034683602 cites W2126405738 @default.
- W2034683602 cites W2130666470 @default.
- W2034683602 cites W2138807559 @default.
- W2034683602 cites W2141077485 @default.
- W2034683602 cites W2142814228 @default.
- W2034683602 cites W2148095358 @default.
- W2034683602 cites W2156478639 @default.
- W2034683602 cites W2156624302 @default.
- W2034683602 cites W2156915517 @default.
- W2034683602 cites W2157191792 @default.
- W2034683602 cites W2161035895 @default.
- W2034683602 cites W2161929236 @default.
- W2034683602 cites W2162387061 @default.
- W2034683602 cites W2167507562 @default.
- W2034683602 cites W2167926698 @default.
- W2034683602 cites W4211191129 @default.
- W2034683602 cites W4232162600 @default.
- W2034683602 cites W4245898328 @default.
- W2034683602 doi "https://doi.org/10.1097/mot.0b013e3283615d48" @default.
- W2034683602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23619515" @default.
- W2034683602 hasPublicationYear "2013" @default.
- W2034683602 type Work @default.
- W2034683602 sameAs 2034683602 @default.
- W2034683602 citedByCount "32" @default.
- W2034683602 countsByYear W20346836022014 @default.
- W2034683602 countsByYear W20346836022015 @default.
- W2034683602 countsByYear W20346836022016 @default.