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• W2034683824 abstract "Mammalian cells produce reactive oxygen and nitrogen species (ROS/RNOS) in response to an oxidative environment. Powerful antioxidant mechanisms have been developed in order to avoid oxidative stress by contributing to the maintenance of redox homeostasis. Traditionally, accumulation of ROS/RNOS is considered deleterious for cells as it can lead to loss of cellular function, aging, and cell death. Consequently, ROS/RNOS imbalance has been implicated in the etiology and/or progression of numerous pathologies such as cardiovascular diseases, inflammation, and cancer. An interesting concept that has emerged more recently is that not only have cells developed efficient systems to cope with ROS/RNOS accumulation but they have also learned to profit of them under certain circumstances. This notion is supported by data showing that ROS/RNOS can act as signaling molecules affecting the function and activity of a multiplicity of protein kinases and phosphatases controlling cellular homeostasis. This review does not provide an exhaustive overview of molecular mechanisms linked to ROS/RNOS generation and processing but includes relevant examples highlighting the dichotomic nature of these small molecules and the multitude of effects elicited by their accumulation. This aspect of ROS/RNOS ought to be taken into account particularly in novel therapeutic setups that aim to achieve high efficiency and minimal or no side effects." @default.
• W2034683824 created "2016-06-24" @default.
• W2034683824 creator A5047661121 @default.
• W2034683824 creator A5068328382 @default.
• W2034683824 creator A5079460105 @default.
• W2034683824 date "2013-11-01" @default.
• W2034683824 modified "2023-09-23" @default.
• W2034683824 title "The Yin and Yang of redox regulation" @default.
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• W2034683824 doi "https://doi.org/10.1179/1351000213y.0000000059" @default.
• W2034683824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6837357" @default.
• W2034683824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24112960" @default.
• W2034683824 hasPublicationYear "2013" @default.
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