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• W2034687464 abstract "Filamin plays an important role in actin cytoskeleton organization, membrane stabilization, and anchoring of transmembrane proteins. Using short interfering RNA (siRNA) to selectively target the filamin A gene and silence its expression, we studied the role of filamin A in G protein coupled receptor (GPCR) signaling. Silencing of filamin A protein expression was determined by immunoblotting and immunofluorescence. Functional consequences of filamin A gene silencing were measured by studying its role in MAPK signaling pathways activated by the Ca2+-sensing receptor. This work defines filamin A involvement in GPCR signaling pathways and describes an additional method for studying its function." @default.
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• W2034687464 date "2006-02-24" @default.
• W2034687464 modified "2023-10-14" @default.
• W2034687464 title "Silencing of filamin A gene expression inhibits Ca²⁺-sensing receptor signaling" @default.
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• W2034687464 doi "https://doi.org/10.1016/j.febslet.2006.02.035" @default.
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