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- W2034688612 endingPage "1367" @default.
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- W2034688612 abstract "Targeting metabolism to tackle seizures About 1% of us suffer from epilepsy. Unfortunately, presently available drugs do not work for a third of epileptic patients. Sada et al. wanted to develop compounds to treat drug-resistant epilepsy (see the Perspective by Scharfman). They focused on a metabolic pathway in the brain, the astrocyte-neuron lactate shuttle. They found that lactate dehydrogenase, a key molecule in nerve cell metabolism, controls brain excitability. Searching for a substance that selectively targets this molecule, they found a potential anti-epileptic drug that strongly suppressed drug-resistant epilepsy in an animal model. Science , this issue p. 1362 ; see also p. 1312" @default.
- W2034688612 created "2016-06-24" @default.
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- W2034688612 date "2015-03-20" @default.
- W2034688612 modified "2023-10-16" @default.
- W2034688612 title "Targeting LDH enzymes with a stiripentol analog to treat epilepsy" @default.
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- W2034688612 doi "https://doi.org/10.1126/science.aaa1299" @default.
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