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- W2034689352 abstract "Mast cells (MC) are pivotal in wound healing. Adelmidrol, a synthetic autacoid, can down-regulate MC degranulation and potentially accelerate healing and improve cosmetic outcome. This study evaluated an Adelmidrol gel on MC in experimental wounds. Two rows of six 5-mm wounds were created in 10 beagles and allowed to heal; one row was treated daily with therapeutic gel and the other with vehicle only. Treated and control 8-mm samples of wounds were taken after 1, 2, 4, 8 and 14 days, fixed in formalin and paraffin embedded. Four-micrometer sections were stained with toluidine blue for MC counts and densitometry. Counts (MC/mm2) were obtained from areas lateral to and within the ulcer/granulation tissue, and in deep dermis/panniculus. A decreasing trend in MC counts occurred throughout days 1 (3.8 ± 11.3), 2 (4.3 ± 14.9) and 4 (4.3 ± 9.9) compared to day 0 (5.0 ± 10.6), followed by an increase at day 8 (6.0 ± 12.3) and a significant increase at day 14 (10.0 ± 18) compared to days 1, 2 and 4 in granulation tissue and perifollicular areas (P < 0.05) and deep dermis/panniculus (P < 0.01). No difference in MC counts was detected between treated andcontrol wounds. Preliminary data from two dogs showed granulation density was higher in treated wounds from day 2 (119.1 ± 27.4 vs. 69.4 ± 14.2) until day 14 (92.4 ± 22.1 vs. 67.9 ± 12.9). In conclusion, MC populations seem to change during wound healing. The autacoid gel did not alter MC numbers, but decreased degranulation. Funding: Royal Veterinary College, Innovet." @default.
- W2034689352 created "2016-06-24" @default.
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- W2034689352 date "2004-08-01" @default.
- W2034689352 modified "2023-09-26" @default.
- W2034689352 title "FC-59 Mast cell morphometry of cutaneous wounds treated with an autacoid gel: a placebo- controlled study" @default.
- W2034689352 doi "https://doi.org/10.1111/j.1365-3164.2004.411_59.x" @default.
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