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- W2034690425 abstract "Background Triple negative breast cancers (TNC) are increasingly reported to be associated with higher grade cancers and worse prognosis. TNC are also known to be associated with BRCA mutation. There have also been reports that apart from differences biologically, reproductive, socio-demographics factors such as age of menarche, age of pregnancy, parity, body mass index may influence the development of TNC. The importance of variations in different ethnicities based on studies on Caucasians and African-Americans (AA) have been emphasized. This study aims to look at the tumor characteristics and factors which may influence the presentation and prognosis of TNC in a cohort of Chinese women. Materials and Method A retrospective review was performed in a prospectively collected database of breast cancer patients between 1996-2007. Clincopathological, epidemiological variables and clinical outcomes were evaluated. Results A total of 924 women with breast cancer were included in this cohort of which 142 (8.2%) had TNC and 782 (45.2%) had non TNC. There was no significant difference in age of presentation in both groups (mean age 52.5 vs 52.1 years old). TNC significantly more likely to be associated with higher grade (p Discussion The percentage of TNC in this cohort is smaller than that reported in the West. Unlike the West, TNC did not present at a younger age. Although TNC and Non TNC have similar stage of presentation, the DFS and OS are worse in TNC which may be explained by the higher histological grade and likely more aggressive biological characteristics. Local recurrence rate after lumpectomy is also higher in TNC which may be related to higher rate of LVI. There are similarities and differences in associated socio-demographic factors compared to the West and a higher rate of BRCA mutation in TNC. Larger-scale study on different ethnicities will increase our understanding in TNC to achieve more personalized management. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3071." @default.
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- W2034690425 date "2009-12-15" @default.
- W2034690425 modified "2023-10-01" @default.
- W2034690425 title "The Epidemiology, Clinico-Pathologic and Prognostic Characteristics of Triple-Negative Breast Cancer Compared with Non Triple-Negative Breast Cancer." @default.
- W2034690425 doi "https://doi.org/10.1158/0008-5472.sabcs-09-3071" @default.
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