Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034691268> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2034691268 endingPage "164" @default.
- W2034691268 startingPage "153" @default.
- W2034691268 abstract "9-Deoxo-16, 16-dimethyl-9-methylene-PGE2 is a new prostaglandin analogue which is stable in suppository form. Estimates of potential for gastrointestinal side effects in monkey in vivo indicated that the frequency of diarrhea was low with retention of uterine stimulating potency. In the present study the effect of the compound on uterine contractility and its efficacy for cervical dilatation and for termination of pregnancy during the second trimester was evaluated in 89 women. The uterine stimulating potency of 9-deoxo-16, 16-dimethyl-9-methylene-PGE2 during mid-pregnancy following bolus intravenous injection or intravenous infusion was four to five times that of PGE2 alpha. Pretreatment with one single vaginal suppository containing 40 mg of the 9-methylene analogue resulted in dilatation of the cervical canal sufficiently to allow evacuation of the uterus without further dilatation in most patients in the 13th to 14th week of pregnancy. In more advanced pregnancies (15th to 24th week of gestation), 83 percent of the patients aborted following vaginal administration of 75 mg of the compound at 0 and 8 hours. All patients had aborted 42 hours after start of treatment if intramuscular injections of 15-methyl-PGE2alpha Tham were added after 24 hours. Both treatments were associated with a significantly lower frequency of gastrointestinal side effects than following vaginal administration of 15-methyl-PGF2alpha methyl ester. The incidence of temperature elevation on the other hand seemed to be higher.9-Deoxo-16,16-dimethyl-9-methylene-PGE2, is a new prostaglandin analogue which is stable in suppository form. Estimates of potential for gastrointestinal side effects in monkeys in vivo indicated that the frequency of diarrhea was low with retention of uterine stimulating potency. In the present study, the effect of the compound on uterine contractility and its efficacy for cervical dilatation and termination of pregnancy during the second trimester was evaluated in 89 women. The uterine stimulating potency of 9-deoxo-16,16-dimethyl-9-methylene-PGE2 during midpregnancy following bolus intravenous injection or intravenous infusion was 4-5 times that of PGF2alpha. Pretreatment with 1 single vaginal suppository containing 40 mg of the analogue resulted in dilatation of the cervical canal sufficiently to allow evacuation of the uterus without further dilatation in most patients in the 13th-14th weeks of pregnancy. In more advanced pregnancies (15-24 weeks), 83% of the patients aborted following vaginal administration of 75 mg of the compound at 0 and 8 hours. All patients had aborted 42 hours after the start of treatment if intramuscular injections of 15-methyl-PGF2alpha Tham were added after 24 hours. Both treatments were associated with a significantly lower frequency of gastrointestinal side effects than followng vaginal administration of 15-methyl-PGF2alpha methyl ester. The incidence of temperature elevation on the other hand appeared to be higher." @default.
- W2034691268 created "2016-06-24" @default.
- W2034691268 creator A5002750938 @default.
- W2034691268 creator A5008076365 @default.
- W2034691268 creator A5068717495 @default.
- W2034691268 creator A5038236628 @default.
- W2034691268 date "1980-08-01" @default.
- W2034691268 modified "2023-10-17" @default.
- W2034691268 title "Mid-trimester abortion by vaginal administration of 9-deoxo-16, 16-dimethyl-9-methylene-PGE2" @default.
- W2034691268 cites W1971275317 @default.
- W2034691268 cites W1976465451 @default.
- W2034691268 cites W2006805343 @default.
- W2034691268 cites W2030553683 @default.
- W2034691268 cites W2038054919 @default.
- W2034691268 cites W2056503736 @default.
- W2034691268 cites W2070801021 @default.
- W2034691268 cites W2085539886 @default.
- W2034691268 doi "https://doi.org/10.1016/0010-7824(80)90059-1" @default.
- W2034691268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7449380" @default.
- W2034691268 hasPublicationYear "1980" @default.
- W2034691268 type Work @default.
- W2034691268 sameAs 2034691268 @default.
- W2034691268 citedByCount "20" @default.
- W2034691268 crossrefType "journal-article" @default.
- W2034691268 hasAuthorship W2034691268A5002750938 @default.
- W2034691268 hasAuthorship W2034691268A5008076365 @default.
- W2034691268 hasAuthorship W2034691268A5038236628 @default.
- W2034691268 hasAuthorship W2034691268A5068717495 @default.
- W2034691268 hasConcept C121608353 @default.
- W2034691268 hasConcept C126322002 @default.
- W2034691268 hasConcept C141071460 @default.
- W2034691268 hasConcept C202751555 @default.
- W2034691268 hasConcept C2777479560 @default.
- W2034691268 hasConcept C2777740455 @default.
- W2034691268 hasConcept C2777744392 @default.
- W2034691268 hasConcept C2778042862 @default.
- W2034691268 hasConcept C2778723060 @default.
- W2034691268 hasConcept C2779066055 @default.
- W2034691268 hasConcept C2779234561 @default.
- W2034691268 hasConcept C2779526769 @default.
- W2034691268 hasConcept C2780664492 @default.
- W2034691268 hasConcept C42219234 @default.
- W2034691268 hasConcept C54355233 @default.
- W2034691268 hasConcept C55493867 @default.
- W2034691268 hasConcept C57992300 @default.
- W2034691268 hasConcept C71924100 @default.
- W2034691268 hasConcept C86803240 @default.
- W2034691268 hasConcept C98274493 @default.
- W2034691268 hasConceptScore W2034691268C121608353 @default.
- W2034691268 hasConceptScore W2034691268C126322002 @default.
- W2034691268 hasConceptScore W2034691268C141071460 @default.
- W2034691268 hasConceptScore W2034691268C202751555 @default.
- W2034691268 hasConceptScore W2034691268C2777479560 @default.
- W2034691268 hasConceptScore W2034691268C2777740455 @default.
- W2034691268 hasConceptScore W2034691268C2777744392 @default.
- W2034691268 hasConceptScore W2034691268C2778042862 @default.
- W2034691268 hasConceptScore W2034691268C2778723060 @default.
- W2034691268 hasConceptScore W2034691268C2779066055 @default.
- W2034691268 hasConceptScore W2034691268C2779234561 @default.
- W2034691268 hasConceptScore W2034691268C2779526769 @default.
- W2034691268 hasConceptScore W2034691268C2780664492 @default.
- W2034691268 hasConceptScore W2034691268C42219234 @default.
- W2034691268 hasConceptScore W2034691268C54355233 @default.
- W2034691268 hasConceptScore W2034691268C55493867 @default.
- W2034691268 hasConceptScore W2034691268C57992300 @default.
- W2034691268 hasConceptScore W2034691268C71924100 @default.
- W2034691268 hasConceptScore W2034691268C86803240 @default.
- W2034691268 hasConceptScore W2034691268C98274493 @default.
- W2034691268 hasIssue "2" @default.
- W2034691268 hasLocation W20346912681 @default.
- W2034691268 hasLocation W20346912682 @default.
- W2034691268 hasOpenAccess W2034691268 @default.
- W2034691268 hasPrimaryLocation W20346912681 @default.
- W2034691268 hasRelatedWork W2049208086 @default.
- W2034691268 hasRelatedWork W2126345351 @default.
- W2034691268 hasRelatedWork W2258710342 @default.
- W2034691268 hasRelatedWork W2277366717 @default.
- W2034691268 hasRelatedWork W2626635252 @default.
- W2034691268 hasRelatedWork W3039022186 @default.
- W2034691268 hasRelatedWork W3048210555 @default.
- W2034691268 hasRelatedWork W3086256864 @default.
- W2034691268 hasRelatedWork W1667968515 @default.
- W2034691268 hasRelatedWork W2189402814 @default.
- W2034691268 hasVolume "22" @default.
- W2034691268 isParatext "false" @default.
- W2034691268 isRetracted "false" @default.
- W2034691268 magId "2034691268" @default.
- W2034691268 workType "article" @default.