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• W2034691756 startingPage "59" @default.
• W2034691756 abstract "Elevated levels of lactic acid can be deleterious to CNS tissue. Lactic acid is known to cause astroglial swelling and since glial swelling has been shown to inhibit l-glutamate (l-Glu) uptake, we examined whether one of the actions of lactic acid is to inhibit l-Glu uptake. Astrocyte cultures treated with lactic acid (25 mM; pH 6.1) showed an inhibition of l-Glu uptake by 65%. HCl (pH 6.1) also inhibited l-Glu uptake and this inhibition was potentiated by sodium lactate (25 mM). The inhibitory effect of lactic acid on l-Glu uptake was partially reversible and the reversibility was enhanced by hypothermia. Blocking glial swelling with d-mannitol, or treatment with antioxidants or hypothermia did not inhibit the effect of lactic acid on l-Glu uptake, indicating that swelling per se or free radicals, were not the factors in l-Glu uptake inhibition. Lactic acid induced a four-fold enhancement of l-Glu release and a seven-fold increase of K+ release. Our results suggest that lactic acid, by direct effect on pH, brings about a stimulation of K+ and l-Glu release which may be a factor in the inhibition of l-Glu uptake by lactic acid in astrocytes." @default.
• W2034691756 created "2016-06-24" @default.
• W2034691756 creator A5054202830 @default.
• W2034691756 creator A5078055631 @default.
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• W2034691756 date "1997-03-01" @default.
• W2034691756 modified "2023-10-16" @default.
• W2034691756 title "Effect of lactic acid on l-glutamate uptake in cultured astrocytes: mechanistic considerations" @default.
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• W2034691756 doi "https://doi.org/10.1016/s0006-8993(96)01331-5" @default.
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