Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034691837> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2034691837 endingPage "301" @default.
- W2034691837 startingPage "289" @default.
- W2034691837 abstract "Addition of a 50 mm dosage of hydroxyurea (HU) to growing cultures of the cilitate Tetrahymena pyriformis allows cell growth to continue but inhibits DNA synthesis, and inhibits cell division after a 20–30% increase in cell number. Higher concentrations of HU cause cell death. T. pyriformis strain differences exist in sensitivity to HU. No cytotoxicity selective to a specific phase of the cell cycle could be demonstrated. The inhibitory effects of HU are entirely reversed by removal of HU and this procedure can be used to induce cell cycle synchrony. Supplementing HU treated cells with deoxyribonucleosides relieves the inhibitory action of HU. Carbamoyloxyurea (COU) is a reactive intermediate of HU and its action on Tetrahymena appears to be similar to that of HU. Because of this similarity and because COU is more potent than HU we postulate that COU is responsible for the unique properties previously ascribed to HU." @default.
- W2034691837 created "2016-06-24" @default.
- W2034691837 creator A5048933670 @default.
- W2034691837 creator A5061883181 @default.
- W2034691837 date "1973-05-01" @default.
- W2034691837 modified "2023-09-24" @default.
- W2034691837 title "ACTION OF HYDROXYUREA AND N-CARBAMOYLOXYUREA ON THE CELL CYCLE OF TETRAHYMENA" @default.
- W2034691837 cites W1586514375 @default.
- W2034691837 cites W1966833017 @default.
- W2034691837 cites W2019578579 @default.
- W2034691837 cites W2030750079 @default.
- W2034691837 cites W2107275518 @default.
- W2034691837 cites W2135596429 @default.
- W2034691837 cites W2145696031 @default.
- W2034691837 doi "https://doi.org/10.1111/j.1365-2184.1973.tb01618.x" @default.
- W2034691837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4633599" @default.
- W2034691837 hasPublicationYear "1973" @default.
- W2034691837 type Work @default.
- W2034691837 sameAs 2034691837 @default.
- W2034691837 citedByCount "10" @default.
- W2034691837 countsByYear W20346918372013 @default.
- W2034691837 crossrefType "journal-article" @default.
- W2034691837 hasAuthorship W2034691837A5048933670 @default.
- W2034691837 hasAuthorship W2034691837A5061883181 @default.
- W2034691837 hasConcept C109316439 @default.
- W2034691837 hasConcept C134018914 @default.
- W2034691837 hasConcept C1491633281 @default.
- W2034691837 hasConcept C153911025 @default.
- W2034691837 hasConcept C17077164 @default.
- W2034691837 hasConcept C185592680 @default.
- W2034691837 hasConcept C202751555 @default.
- W2034691837 hasConcept C2777166614 @default.
- W2034691837 hasConcept C29537977 @default.
- W2034691837 hasConcept C2991723024 @default.
- W2034691837 hasConcept C552990157 @default.
- W2034691837 hasConcept C55493867 @default.
- W2034691837 hasConcept C62112901 @default.
- W2034691837 hasConcept C64241487 @default.
- W2034691837 hasConcept C85813293 @default.
- W2034691837 hasConcept C86803240 @default.
- W2034691837 hasConcept C95444343 @default.
- W2034691837 hasConceptScore W2034691837C109316439 @default.
- W2034691837 hasConceptScore W2034691837C134018914 @default.
- W2034691837 hasConceptScore W2034691837C1491633281 @default.
- W2034691837 hasConceptScore W2034691837C153911025 @default.
- W2034691837 hasConceptScore W2034691837C17077164 @default.
- W2034691837 hasConceptScore W2034691837C185592680 @default.
- W2034691837 hasConceptScore W2034691837C202751555 @default.
- W2034691837 hasConceptScore W2034691837C2777166614 @default.
- W2034691837 hasConceptScore W2034691837C29537977 @default.
- W2034691837 hasConceptScore W2034691837C2991723024 @default.
- W2034691837 hasConceptScore W2034691837C552990157 @default.
- W2034691837 hasConceptScore W2034691837C55493867 @default.
- W2034691837 hasConceptScore W2034691837C62112901 @default.
- W2034691837 hasConceptScore W2034691837C64241487 @default.
- W2034691837 hasConceptScore W2034691837C85813293 @default.
- W2034691837 hasConceptScore W2034691837C86803240 @default.
- W2034691837 hasConceptScore W2034691837C95444343 @default.
- W2034691837 hasIssue "3" @default.
- W2034691837 hasLocation W20346918371 @default.
- W2034691837 hasLocation W20346918372 @default.
- W2034691837 hasOpenAccess W2034691837 @default.
- W2034691837 hasPrimaryLocation W20346918371 @default.
- W2034691837 hasRelatedWork W2008217391 @default.
- W2034691837 hasRelatedWork W2012886043 @default.
- W2034691837 hasRelatedWork W2045531509 @default.
- W2034691837 hasRelatedWork W2062057385 @default.
- W2034691837 hasRelatedWork W2068356852 @default.
- W2034691837 hasRelatedWork W2072481810 @default.
- W2034691837 hasRelatedWork W2169772975 @default.
- W2034691837 hasRelatedWork W2523946566 @default.
- W2034691837 hasRelatedWork W4280493527 @default.
- W2034691837 hasRelatedWork W2466354640 @default.
- W2034691837 hasVolume "6" @default.
- W2034691837 isParatext "false" @default.
- W2034691837 isRetracted "false" @default.
- W2034691837 magId "2034691837" @default.
- W2034691837 workType "article" @default.