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• W2034691857 abstract "Cell-membrane raft microdomains are important for successful infection by several viruses. However, their role in the cell-entry process of human herpesvirus-6 (HHV-6) is unknown. Here we tested whether HHV-6 requires cell-membrane rafts for its entry. When cell-membrane rafts were disrupted by cholesterol depletion, target-cell entry by HHV-6 was inhibited, although the virus bound normally to the cells. HHV-6 infectivity was partially rescued by adding exogenous cholesterol. Interestingly, the HHV-6 cellular receptor, CD46, was found in the rafts after virus attachment, but not in the rafts of uninfected cells, indicating that HHV-6 infection induces the re-location of its receptor into the rafts. Furthermore, glycoprotein Q1, part of a viral glycoprotein complex that binds CD46, was also associated with rafts immediately after infection. These data suggest that cellular-membrane lipid rafts are important in viral entry and that HHV-6 may enter the target cells via the rafts." @default.
• W2034691857 created "2016-06-24" @default.
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• W2034691857 date "2008-09-01" @default.
• W2034691857 modified "2023-10-16" @default.
• W2034691857 title "Human herpesvirus-6 infection induces the reorganization of membrane microdomains in target cells, which are required for virus entry" @default.
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• W2034691857 doi "https://doi.org/10.1016/j.virol.2008.05.028" @default.
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