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- W2034693580 abstract "<b><i>Background:</i></b> Heme oxygenase (HO) is the initial, rate-limiting enzyme in the conversion of heme to bilirubin. Dinucleotide (GT)<sub>n</sub> repeat length in the promoter region of the encoding gene modulates transcription: shorter alleles, in contrast with longer allele counterparts, are associated with greater gene expression and should result in increased heme catabolism. <b><i>Objective:</i></b> We compared the rates of heme catabolism and plasma total bilirubin (TB) between <i>HO-1</i> promoter genotypes of varying (GT)<sub>n</sub> repeat lengths in glucose-6-phosphate dehydrogenase (G6PD)-normal and -deficient neonates. <b><i>Methods:</i></b><i>HO-1</i> promoter length was determined from genomic DNA from previous studies by size discrimination of fluorescently-labeled PCR products with capillary electrophoresis. Sizing was confirmed by sequencing homozygote samples. Alleles were categorized as: short (≤24 GT repeats), medium (25-33 GT repeats), and long (≥34 GT repeats). Previously determined values for blood carboxyhemoglobin, corrected for inspired carbon monoxide (COHbc), and TB were used to determine the rate of heme catabolism and 3rd day TB values for each <i>HO-1</i> promoter length genotype, respectively. <i>G6PD Mediterranean</i> was determined by PCR analysis. <b><i>Results:</i></b> Neither COHbc nor TB values were significantly different between various <i>HO-1</i> promoter genotypes for either G6PD-normal or -deficient neonates. <b><i>Conclusions:</i></b> In the steady state, <i>HO-1</i> promoter genotypes, based on the length of (GT)<sub>n</sub> repeats, do not modulate heme catabolism or 3rd day TB values in either G6PD-normal or -deficient neonates." @default.
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- W2034693580 date "2014-01-01" @default.
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- W2034693580 title "<b><i>Heme Oxygenase-1</i></b> Promoter Polymorphisms and Neonatal Jaundice" @default.
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- W2034693580 doi "https://doi.org/10.1159/000365744" @default.
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