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• W2034693740 abstract "Spreading cortical depression (SCD) alters cerebral blood flow by mechanisms that are not well understood. To investigate the role of the likely endothelium-derived relaxing factor, nitric oxide, in the blood flow changes occurring during SCD in awake rats, nitric oxide synthesis was blocked using Nw-nitro-l-arginine methyl ester (l-NAME). During SCD there is an initial hyperperfusion followed by a longer-lasting hypoperfusion. Treatment with l-NAME, 30 mg/kg, reduced resting cerebral blood flow globally. During SCD, l-NAME treatment produced an additional brief phase of hypoperfusion which preceded the initial hyperperfusion. The magnitude of the initial hyperperfusion was less than expected. The subsequent longer-lasting hypoperfusion was unchanged. Nitric oxide plays an important role in the regulation of cerebral blood flow during SCD." @default.
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• W2034693740 date "1993-08-01" @default.
• W2034693740 modified "2023-10-18" @default.
• W2034693740 title "A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited" @default.
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• W2034693740 doi "https://doi.org/10.1016/0006-8993(93)91265-t" @default.
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