Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034694022> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2034694022 endingPage "165" @default.
- W2034694022 startingPage "163" @default.
- W2034694022 abstract "Introduction Bivalirudin is used as an alternative to heparin in cardiac surgery, and may be superior to heparin with regard to platelet function. Bivalirudin however, is prone to cleavage by thrombin resulting in coagulation in areas of stasis. Material and Methods We compared the preservation of platelet function and the quality of anticoagulation in autologous blood of 26 cardiac surgical patients collected intraoperatively and anticoagulated ex vivo with either bivalirudin or heparin, with supplementation of bivalirudin over time and prevention of stasis. Results We found in both preservatives a reduction in ADP-induced platelet aggregation response over a period of 105 minutes (median, IQR: 73–141) as measured by Multiplate®. Supplementation of additional bivalirudin (23±1.1 μg/ml/hr) and prevention of stasis was not able to prevent thrombin generation. We found a 5-fold increase in levels of prothrombin fragment 1+2 in bivalirudin preserved autologous blood as compared to heparin preserved blood (F1+2 levels median 8.9 nM [quartile percentiles 4.2-12.4] vs 1.3 nM [0.6-2.1], P=0.001 Mann–Whitney, n=10). Conclusions Our study suggests that preservation of platelet function in autologous blood anticoagulated with bivalirudin is not a suitable alternative to heparin." @default.
- W2034694022 created "2016-06-24" @default.
- W2034694022 creator A5051531684 @default.
- W2034694022 creator A5074302578 @default.
- W2034694022 creator A5079055505 @default.
- W2034694022 creator A5047464790 @default.
- W2034694022 date "2012-08-01" @default.
- W2034694022 modified "2023-09-26" @default.
- W2034694022 title "Bivalirudin is inferior to heparin in preservation of intraoperative autologous blood" @default.
- W2034694022 cites W171420448 @default.
- W2034694022 cites W1988608065 @default.
- W2034694022 cites W1996805811 @default.
- W2034694022 cites W2009061410 @default.
- W2034694022 cites W2036829694 @default.
- W2034694022 cites W2037184883 @default.
- W2034694022 cites W2042275984 @default.
- W2034694022 cites W2046876029 @default.
- W2034694022 cites W2049036705 @default.
- W2034694022 cites W2051598119 @default.
- W2034694022 cites W2052555307 @default.
- W2034694022 cites W2054059900 @default.
- W2034694022 cites W2071592148 @default.
- W2034694022 cites W2077857883 @default.
- W2034694022 cites W2084529909 @default.
- W2034694022 cites W2111773029 @default.
- W2034694022 cites W2130219973 @default.
- W2034694022 cites W2140970829 @default.
- W2034694022 cites W4238696256 @default.
- W2034694022 doi "https://doi.org/10.1016/j.thromres.2011.12.024" @default.
- W2034694022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22261478" @default.
- W2034694022 hasPublicationYear "2012" @default.
- W2034694022 type Work @default.
- W2034694022 sameAs 2034694022 @default.
- W2034694022 citedByCount "2" @default.
- W2034694022 countsByYear W20346940222014 @default.
- W2034694022 countsByYear W20346940222018 @default.
- W2034694022 crossrefType "journal-article" @default.
- W2034694022 hasAuthorship W2034694022A5047464790 @default.
- W2034694022 hasAuthorship W2034694022A5051531684 @default.
- W2034694022 hasAuthorship W2034694022A5074302578 @default.
- W2034694022 hasAuthorship W2034694022A5079055505 @default.
- W2034694022 hasConcept C126322002 @default.
- W2034694022 hasConcept C141071460 @default.
- W2034694022 hasConcept C164705383 @default.
- W2034694022 hasConcept C2776301958 @default.
- W2034694022 hasConcept C2776710957 @default.
- W2034694022 hasConcept C2777557582 @default.
- W2034694022 hasConcept C2777565915 @default.
- W2034694022 hasConcept C2778205648 @default.
- W2034694022 hasConcept C2778261982 @default.
- W2034694022 hasConcept C2778810321 @default.
- W2034694022 hasConcept C2779161974 @default.
- W2034694022 hasConcept C2780400711 @default.
- W2034694022 hasConcept C42219234 @default.
- W2034694022 hasConcept C500558357 @default.
- W2034694022 hasConcept C71924100 @default.
- W2034694022 hasConcept C89560881 @default.
- W2034694022 hasConceptScore W2034694022C126322002 @default.
- W2034694022 hasConceptScore W2034694022C141071460 @default.
- W2034694022 hasConceptScore W2034694022C164705383 @default.
- W2034694022 hasConceptScore W2034694022C2776301958 @default.
- W2034694022 hasConceptScore W2034694022C2776710957 @default.
- W2034694022 hasConceptScore W2034694022C2777557582 @default.
- W2034694022 hasConceptScore W2034694022C2777565915 @default.
- W2034694022 hasConceptScore W2034694022C2778205648 @default.
- W2034694022 hasConceptScore W2034694022C2778261982 @default.
- W2034694022 hasConceptScore W2034694022C2778810321 @default.
- W2034694022 hasConceptScore W2034694022C2779161974 @default.
- W2034694022 hasConceptScore W2034694022C2780400711 @default.
- W2034694022 hasConceptScore W2034694022C42219234 @default.
- W2034694022 hasConceptScore W2034694022C500558357 @default.
- W2034694022 hasConceptScore W2034694022C71924100 @default.
- W2034694022 hasConceptScore W2034694022C89560881 @default.
- W2034694022 hasIssue "2" @default.
- W2034694022 hasLocation W20346940221 @default.
- W2034694022 hasLocation W20346940222 @default.
- W2034694022 hasOpenAccess W2034694022 @default.
- W2034694022 hasPrimaryLocation W20346940221 @default.
- W2034694022 hasRelatedWork W1946073935 @default.
- W2034694022 hasRelatedWork W1989049428 @default.
- W2034694022 hasRelatedWork W2065797774 @default.
- W2034694022 hasRelatedWork W2085906645 @default.
- W2034694022 hasRelatedWork W2183433007 @default.
- W2034694022 hasRelatedWork W2236393536 @default.
- W2034694022 hasRelatedWork W2254732075 @default.
- W2034694022 hasRelatedWork W2270840170 @default.
- W2034694022 hasRelatedWork W2413647999 @default.
- W2034694022 hasRelatedWork W2789957772 @default.
- W2034694022 hasVolume "130" @default.
- W2034694022 isParatext "false" @default.
- W2034694022 isRetracted "false" @default.
- W2034694022 magId "2034694022" @default.
- W2034694022 workType "article" @default.