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• W2034694119 startingPage "539" @default.
• W2034694119 abstract "The function of natural-killer (NK) cells is modulated by the balance between a number of activating and inhibitory receptors. Killer immunoglobulinlike receptors (KIRs) are mostly inhibitory receptors. They play a critical role in recognizing self-class-I major histocompatibility complex (MHC) molecules and thus protect healthy host cells from NK-targeted lysis. In contrast, both NKG2D and CD16 are activating NK receptors that trigger the NK-cell lysis of various tumor and virally infected cells through either direct ligand engagement or antibody-dependent cellular cytotoxicity (ADCC). Through structural studies of members of these distinct receptor families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their ligand recognition." @default.
• W2034694119 created "2016-06-24" @default.
• W2034694119 creator A5045555496 @default.
• W2034694119 date "2003-01-01" @default.
• W2034694119 modified "2023-10-16" @default.
• W2034694119 title "Structure and Function of Natural-Killer-Cell Receptors" @default.
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• W2034694119 doi "https://doi.org/10.1385/ir:27:2-3:539" @default.
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• W2034694119 hasPublicationYear "2003" @default.
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