FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034696501> ?p ?o ?g. }

• W2034696501 endingPage "e63387" @default.
• W2034696501 startingPage "e63387" @default.
• W2034696501 abstract "Although Anopheles mosquitoes are the vectors for human Plasmodium spp., there are also other mosquito species-among them culicines (Culex spp., Aedes spp.)-present in malaria-endemic areas. Culicine mosquitoes transmit arboviruses and filarial worms to humans and are vectors for avian Plasmodium spp., but have never been observed to transmit human Plasmodium spp. When ingested by a culicine mosquito, parasites could either face an environment that does not allow development due to biologic incompatibility or be actively killed by the mosquito's immune system. In the latter case, the molecular mechanism of killing must be sufficiently powerful that Plasmodium is not able to overcome it. To investigate how human malaria parasites develop in culicine mosquitoes, we infected Culex quinquefasciatus with Plasmodium falciparum NF54 and monitored development of parasites in the blood bolus and midgut epithelium at different time points. Our results reveal that ookinetes develop in the midgut lumen of C. quinquefasciatus in slightly lower numbers than in Anopheles gambiae G3. After 30 hours, parasites have invaded the midgut and can be observed on the basal side of the midgut epithelium by confocal and transmission electron microscopy. Very few of the parasites in C. quinquefasciatus are alive, most of them are lysed. Eight days after the mosquito's blood meal, no oocysts can be found in C. quinquefasciatus. Our results suggest that the mosquito immune system could be involved in parasite killing early in development after ookinetes have crossed the midgut epithelium and come in contact with the mosquito hemolymph." @default.
• W2034696501 created "2016-06-24" @default.
• W2034696501 creator A5012284780 @default.
• W2034696501 creator A5012685692 @default.
• W2034696501 creator A5033723381 @default.
• W2034696501 creator A5056670181 @default.
• W2034696501 creator A5058192513 @default.
• W2034696501 creator A5077072507 @default.
• W2034696501 creator A5083887946 @default.
• W2034696501 date "2013-05-03" @default.
• W2034696501 modified "2023-10-18" @default.
• W2034696501 title "An Impossible Journey? The Development of Plasmodium falciparum NF54 in Culex quinquefasciatus" @default.
• W2034696501 cites W1968319638 @default.
• W2034696501 cites W1969503178 @default.
• W2034696501 cites W1970465046 @default.
• W2034696501 cites W1974527939 @default.
• W2034696501 cites W1997990702 @default.
• W2034696501 cites W2002204586 @default.
• W2034696501 cites W2007793421 @default.
• W2034696501 cites W2009943836 @default.
• W2034696501 cites W2011247119 @default.
• W2034696501 cites W2016373666 @default.
• W2034696501 cites W2019211309 @default.
• W2034696501 cites W2021653738 @default.
• W2034696501 cites W2025863286 @default.
• W2034696501 cites W2027831884 @default.
• W2034696501 cites W2029949703 @default.
• W2034696501 cites W2033686986 @default.
• W2034696501 cites W2034089944 @default.
• W2034696501 cites W2036868716 @default.
• W2034696501 cites W2039621386 @default.
• W2034696501 cites W2043593786 @default.
• W2034696501 cites W2044199953 @default.
• W2034696501 cites W2057122808 @default.
• W2034696501 cites W2059135947 @default.
• W2034696501 cites W2059164749 @default.
• W2034696501 cites W2061907586 @default.
• W2034696501 cites W2063769573 @default.
• W2034696501 cites W2073024879 @default.
• W2034696501 cites W2080101450 @default.
• W2034696501 cites W2080261333 @default.
• W2034696501 cites W2083279916 @default.
• W2034696501 cites W2084184778 @default.
• W2034696501 cites W2085160743 @default.
• W2034696501 cites W2090502725 @default.
• W2034696501 cites W2098429428 @default.
• W2034696501 cites W2120579606 @default.
• W2034696501 cites W2123392551 @default.
• W2034696501 cites W2125968054 @default.
• W2034696501 cites W2136464215 @default.
• W2034696501 cites W2139101250 @default.
• W2034696501 cites W2142633440 @default.
• W2034696501 cites W2159170889 @default.
• W2034696501 cites W2159405964 @default.
• W2034696501 cites W2166634100 @default.
• W2034696501 cites W2327996507 @default.
• W2034696501 cites W2400295363 @default.
• W2034696501 cites W4232622599 @default.
• W2034696501 cites W4238539801 @default.
• W2034696501 cites W4253861597 @default.
• W2034696501 doi "https://doi.org/10.1371/journal.pone.0063387" @default.
• W2034696501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3643899" @default.
• W2034696501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23658824" @default.
• W2034696501 hasPublicationYear "2013" @default.
• W2034696501 type Work @default.
• W2034696501 sameAs 2034696501 @default.
• W2034696501 citedByCount "8" @default.
• W2034696501 countsByYear W20346965012013 @default.
• W2034696501 countsByYear W20346965012015 @default.
• W2034696501 countsByYear W20346965012016 @default.
• W2034696501 countsByYear W20346965012018 @default.
• W2034696501 countsByYear W20346965012019 @default.
• W2034696501 countsByYear W20346965012021 @default.
• W2034696501 countsByYear W20346965012023 @default.
• W2034696501 crossrefType "journal-article" @default.
• W2034696501 hasAuthorship W2034696501A5012284780 @default.
• W2034696501 hasAuthorship W2034696501A5012685692 @default.
• W2034696501 hasAuthorship W2034696501A5033723381 @default.
• W2034696501 hasAuthorship W2034696501A5056670181 @default.
• W2034696501 hasAuthorship W2034696501A5058192513 @default.
• W2034696501 hasAuthorship W2034696501A5077072507 @default.
• W2034696501 hasAuthorship W2034696501A5083887946 @default.
• W2034696501 hasBestOaLocation W20346965011 @default.
• W2034696501 hasConcept C136764020 @default.
• W2034696501 hasConcept C150149183 @default.
• W2034696501 hasConcept C159047783 @default.
• W2034696501 hasConcept C173758957 @default.
• W2034696501 hasConcept C18903297 @default.
• W2034696501 hasConcept C203014093 @default.
• W2034696501 hasConcept C2776217558 @default.
• W2034696501 hasConcept C2776802408 @default.
• W2034696501 hasConcept C2777775583 @default.
• W2034696501 hasConcept C2777923404 @default.
• W2034696501 hasConcept C2778048844 @default.
• W2034696501 hasConcept C2778371730 @default.
• W2034696501 hasConcept C2778675580 @default.
• W2034696501 hasConcept C2779518617 @default.
• W2034696501 hasConcept C2781375639 @default.

• next