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- W2034697805 abstract "Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface." @default.
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- W2034697805 date "1983-01-01" @default.
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- W2034697805 title "Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta)" @default.
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- W2034697805 doi "https://doi.org/10.1016/0022-1910(83)90146-4" @default.
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