FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034698282> ?p ?o ?g. }

• W2034698282 endingPage "131" @default.
• W2034698282 startingPage "120" @default.
• W2034698282 abstract "Chronic renal failure involves the progressive loss of renal parenchymal cells. For example, Alport syndrome develops from mutated type IV collagen that fosters the digestion of glomerular basement membranes and podocyte loss, followed by progressive glomerulosclerosis, ie Alport nephropathy. Here we show that autosomal recessive Alport nephropathy in collagen 4a3-deficient mice is associated with increased intrarenal expression of the pro-apoptotic cytokine tumour necrosis factor-alpha (TNF-α) in glomerular cells including podocytes as well as in infiltrating leukocytes. We therefore hypothesized that TNF-α contributes to Alport glomerulosclerosis by inducing podocyte apoptosis. To address this issue, we treated 4-week-old collagen 4a3-deficient mice with either vehicle or the TNF-α antagonist etanercept for a period of 5 weeks. Etanercept treatment prolonged mean survival from 68 to 81 days as compared to vehicle-treated mice. The beneficial effect of etanercept on survival was associated with a significant improvement of the glomerulosclerosis score, proteinuria, and the glomerular filtration rate at 9 weeks of age. Etanercept treatment specifically reduced the numbers of apoptotic podocytes, increased total podocyte counts, and increased the renal mRNA expression of nephrin and podocin without affecting markers of renal inflammation. TNF-α-induced podocyte loss is a previously unrecognized pathological mechanism of Alport glomerulosclerosis, and TNF-α blockade might be a therapeutic option to delay the progression of Alport nephropathy and potentially of other forms of glomerulosclerosis." @default.
• W2034698282 created "2016-06-24" @default.
• W2034698282 creator A5020103420 @default.
• W2034698282 creator A5024783922 @default.
• W2034698282 creator A5080336495 @default.
• W2034698282 creator A5082061087 @default.
• W2034698282 creator A5091004058 @default.
• W2034698282 date "2011-09-26" @default.
• W2034698282 modified "2023-10-18" @default.
• W2034698282 title "Tumour necrosis factor-α drives Alport glomerulosclerosis in mice by promoting podocyte apoptosis" @default.
• W2034698282 cites W170942874 @default.
• W2034698282 cites W1967934644 @default.
• W2034698282 cites W1975379618 @default.
• W2034698282 cites W1986829962 @default.
• W2034698282 cites W1988836590 @default.
• W2034698282 cites W1990060718 @default.
• W2034698282 cites W1993936200 @default.
• W2034698282 cites W1998334108 @default.
• W2034698282 cites W1999755139 @default.
• W2034698282 cites W2000915212 @default.
• W2034698282 cites W2003370392 @default.
• W2034698282 cites W2018237806 @default.
• W2034698282 cites W2018509996 @default.
• W2034698282 cites W2057943853 @default.
• W2034698282 cites W2068165090 @default.
• W2034698282 cites W2085473622 @default.
• W2034698282 cites W2085637098 @default.
• W2034698282 cites W2085854349 @default.
• W2034698282 cites W2099547936 @default.
• W2034698282 cites W2101835426 @default.
• W2034698282 cites W2101960634 @default.
• W2034698282 cites W2102235083 @default.
• W2034698282 cites W2104636490 @default.
• W2034698282 cites W2107705756 @default.
• W2034698282 cites W2114397993 @default.
• W2034698282 cites W2114517343 @default.
• W2034698282 cites W2115073390 @default.
• W2034698282 cites W2117631121 @default.
• W2034698282 cites W2120807600 @default.
• W2034698282 cites W2127923616 @default.
• W2034698282 cites W2137054971 @default.
• W2034698282 cites W2142641008 @default.
• W2034698282 cites W2157230648 @default.
• W2034698282 cites W2163406006 @default.
• W2034698282 doi "https://doi.org/10.1002/path.2979" @default.
• W2034698282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21953121" @default.
• W2034698282 hasPublicationYear "2011" @default.
• W2034698282 type Work @default.
• W2034698282 sameAs 2034698282 @default.
• W2034698282 citedByCount "52" @default.
• W2034698282 countsByYear W20346982822012 @default.
• W2034698282 countsByYear W20346982822013 @default.
• W2034698282 countsByYear W20346982822014 @default.
• W2034698282 countsByYear W20346982822015 @default.
• W2034698282 countsByYear W20346982822016 @default.
• W2034698282 countsByYear W20346982822017 @default.
• W2034698282 countsByYear W20346982822018 @default.
• W2034698282 countsByYear W20346982822019 @default.
• W2034698282 countsByYear W20346982822020 @default.
• W2034698282 countsByYear W20346982822021 @default.
• W2034698282 countsByYear W20346982822022 @default.
• W2034698282 countsByYear W20346982822023 @default.
• W2034698282 crossrefType "journal-article" @default.
• W2034698282 hasAuthorship W2034698282A5020103420 @default.
• W2034698282 hasAuthorship W2034698282A5024783922 @default.
• W2034698282 hasAuthorship W2034698282A5080336495 @default.
• W2034698282 hasAuthorship W2034698282A5082061087 @default.
• W2034698282 hasAuthorship W2034698282A5091004058 @default.
• W2034698282 hasConcept C126322002 @default.
• W2034698282 hasConcept C134018914 @default.
• W2034698282 hasConcept C17991360 @default.
• W2034698282 hasConcept C2776115139 @default.
• W2034698282 hasConcept C2776855237 @default.
• W2034698282 hasConcept C2776908417 @default.
• W2034698282 hasConcept C2777146197 @default.
• W2034698282 hasConcept C2777226972 @default.
• W2034698282 hasConcept C2777390665 @default.
• W2034698282 hasConcept C2778415529 @default.
• W2034698282 hasConcept C2779561371 @default.
• W2034698282 hasConcept C2780091579 @default.
• W2034698282 hasConcept C2780368995 @default.
• W2034698282 hasConcept C2780819817 @default.
• W2034698282 hasConcept C2781184683 @default.
• W2034698282 hasConcept C555293320 @default.
• W2034698282 hasConcept C71924100 @default.
• W2034698282 hasConceptScore W2034698282C126322002 @default.
• W2034698282 hasConceptScore W2034698282C134018914 @default.
• W2034698282 hasConceptScore W2034698282C17991360 @default.
• W2034698282 hasConceptScore W2034698282C2776115139 @default.
• W2034698282 hasConceptScore W2034698282C2776855237 @default.
• W2034698282 hasConceptScore W2034698282C2776908417 @default.
• W2034698282 hasConceptScore W2034698282C2777146197 @default.
• W2034698282 hasConceptScore W2034698282C2777226972 @default.
• W2034698282 hasConceptScore W2034698282C2777390665 @default.
• W2034698282 hasConceptScore W2034698282C2778415529 @default.
• W2034698282 hasConceptScore W2034698282C2779561371 @default.
• W2034698282 hasConceptScore W2034698282C2780091579 @default.
• W2034698282 hasConceptScore W2034698282C2780368995 @default.

• next