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- W2034700227 abstract "Background: Oxidative stress is a hallmark of aging and most neurodegenerative diseases such as Alzheimers, Parkinsons, and diffuse Lewy body diseases. Hydrogen peroxide (H2O2) causes free radical generation and apoptosis similar to that present in neurogenerative diseases. It has been thought that H2O2 disorganizes the cortical actin cytoskeleton and, in brain cell extracts, inhibits actin polymerization. Moreover, microtubule network disruption has also been observed in cortical neurons exposed to high levels of free radicals. Melatonin, the main product secreted by the pineal gland, protects the neuronal cells by its action as a free radical scavenger. In addition, this antioxidant inhibits apoptosis and induces microtubule and microfilament reorganization as well as neurite formation in neuronal cultured cells. Objective: In this work, we characterized the effects of H2O2 on neurite structure and studied the effects of melatonin on cytoskeletal organization in N1E-115 cells damaged by H2O2. Methods: M..." @default.
- W2034700227 created "2016-06-24" @default.
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- W2034700227 date "2005-09-01" @default.
- W2034700227 modified "2023-10-18" @default.
- W2034700227 title "Melatonin precludes cytoskeletal collapse caused by hydrogen peroxide: participation of protein kinase C" @default.
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- W2034700227 doi "https://doi.org/10.2217/14750708.2.5.767" @default.
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