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• W2034700257 abstract "ABSTRACT The γ 1 34.5 protein of herpes simplex virus 1 is an essential factor for viral virulence. In infected cells, this viral protein prevents the translation arrest mediated by double-stranded RNA-dependent protein kinase R. Additionally, it associates with and inhibits TANK-binding kinase 1, an essential component of Toll-like receptor-dependent and -independent pathways that activate interferon regulatory factor 3 and cytokine expression. Here, we show that γ 1 34.5 is required to block the maturation of conventional dendritic cells (DCs) that initiate adaptive immune responses. Unlike wild-type virus, the γ 1 34.5 null mutant stimulates the expression of CD86, major histocompatibility complex class II (MHC-II), and cytokines such as alpha/beta interferon in immature DCs. Viral replication in DCs inversely correlates with interferon production. These phenotypes are also mirrored in a mouse ocular infection model. Further, DCs infected with the γ 1 34.5 null mutant effectively activate naïve T cells whereas DCs infected with wild-type virus fail to do so. Type I interferon-neutralizing antibodies partially reverse virus-induced upregulation of CD86 and MHC-II, suggesting that γ 1 34.5 acts through interferon-dependent and -independent mechanisms. These data indicate that γ 1 34.5 is involved in the impairment of innate immunity by inhibiting both type I interferon production and DC maturation, leading to defective T-cell activation." @default.
• W2034700257 created "2016-06-24" @default.
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• W2034700257 date "2009-05-15" @default.
• W2034700257 modified "2023-10-10" @default.
• W2034700257 title "The γ₁34.5 Protein of Herpes Simplex Virus 1 Is Required To Interfere with Dendritic Cell Maturation during Productive Infection" @default.
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• W2034700257 doi "https://doi.org/10.1128/jvi.02535-08" @default.
• W2034700257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2682079" @default.
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