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• W2034700992 abstract "By focusing on 4,5-epoxymorphinan, a traditional opioid skeleton but a new structure in the opioid kappa-agonist research field, and by rationally applying the 'message-address concept' and 'accessory site hypothesis,' we discovered a new chemical class opioid kappa-agonist, TRK-820 (1). Its development as an antipruritus is now in the final stage. Here, the full scope of its design, synthesis, and structure-activity relationship are described." @default.
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• W2034700992 date "2008-10-01" @default.
• W2034700992 modified "2023-10-10" @default.
• W2034700992 title "Design, synthesis, and structure–activity relationship of novel opioid κ-agonists" @default.
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• W2034700992 doi "https://doi.org/10.1016/j.bmc.2008.09.011" @default.
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