FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034704670> ?p ?o ?g. }

• W2034704670 endingPage "165" @default.
• W2034704670 startingPage "160" @default.
• W2034704670 abstract "PTEN gene (10q23) is a relevant tumor suppressor gene whose protein is a phosphatase involved in the control of angiogenesis of some tumors including astrocytomas. There are no studies correlating molecular changes of PTEN and the immunohistochemical expression of its protein (pPTEN) with the expression of vascular endothelial growth factor (VEGF) in astrocytomas. Fifty-six surgically resected brain gliomas, 10 grade 2, 16 grade 3, and 30 grade 4, were studied by a combined approach, consisting of (1) PCR analysis using four microsatellite markers against the PTEN gene region (10q23), (2) the FISH technique to test chromosome 10 using a pericentromeric probe, and (3) immunohistochemical evaluation of pPTEN and VEGF. Loss of heterozygosity (LOH) of PTEN was observed in 10% of fibrillary grade 2 astrocytomas and all gemistocytic ones. In high-grade tumors, LOH was more frequent in grade 4 than in grade 3 (> or =2 loci deleted, 83% and 56%, respectively). Monosomy for chromosome 10 was observed especially in high-grade tumors (6% of grade 3 and 50% of grade 4) and in 20% of grade 2 tumors, corresponding to gemistocytic astrocytomas. Results with both antibodies against PTEN were concordant: loss of cytoplasmic immunoreactivity was frequently observed according to homogeneous or heterogeneous patterns in 70% and 50% of grades 4 and 3, respectively, but not in grade 2. Immunonegativity of pPTEN was associated with PTEN gene deletion (> or =2 loci deleted) (P = 0.04) but not with monosomy. Cytoplasmic immunoreactivity against VEGF was observed in high-grade and in gemistocytic astrocytomas, but not in conventional grade 2 tumors. Tumor expression of pPTEN was not associated with immunoreactivity against VEGF when the same areas were considered. In conclusion, loss of PTEN expression is frequent in high-grade astrocytomas, but not in grade 2 tumors, and correlates with PTEN deletion and loss of chromosome 10. PTEN immunoreactivity does not correlate with VEGF expression in astrocytomas when similar areas are considered." @default.
• W2034704670 created "2016-06-24" @default.
• W2034704670 creator A5015685153 @default.
• W2034704670 creator A5029010643 @default.
• W2034704670 creator A5029140865 @default.
• W2034704670 creator A5044250695 @default.
• W2034704670 creator A5065500205 @default.
• W2034704670 creator A5071006316 @default.
• W2034704670 creator A5081810190 @default.
• W2034704670 creator A5086449835 @default.
• W2034704670 date "2003-09-01" @default.
• W2034704670 modified "2023-09-27" @default.
• W2034704670 title "PTEN Protein Expression Correlates With PTEN Gene Molecular Changes but not With VEGF Expression in Astrocytomas" @default.
• W2034704670 cites W1969328947 @default.
• W2034704670 cites W1976748435 @default.
• W2034704670 cites W1996075333 @default.
• W2034704670 cites W2016919599 @default.
• W2034704670 cites W2026409472 @default.
• W2034704670 cites W2042204791 @default.
• W2034704670 cites W2093062161 @default.
• W2034704670 cites W2093736433 @default.
• W2034704670 cites W2095967371 @default.
• W2034704670 cites W2142786915 @default.
• W2034704670 cites W2143739956 @default.
• W2034704670 cites W2145637828 @default.
• W2034704670 cites W2150621343 @default.
• W2034704670 cites W2316897574 @default.
• W2034704670 cites W2320297010 @default.
• W2034704670 cites W2334048130 @default.
• W2034704670 doi "https://doi.org/10.1097/00019606-200309000-00007" @default.
• W2034704670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12960698" @default.
• W2034704670 hasPublicationYear "2003" @default.
• W2034704670 type Work @default.
• W2034704670 sameAs 2034704670 @default.
• W2034704670 citedByCount "11" @default.
• W2034704670 countsByYear W20347046702012 @default.
• W2034704670 countsByYear W20347046702014 @default.
• W2034704670 countsByYear W20347046702015 @default.
• W2034704670 countsByYear W20347046702016 @default.
• W2034704670 crossrefType "journal-article" @default.
• W2034704670 hasAuthorship W2034704670A5015685153 @default.
• W2034704670 hasAuthorship W2034704670A5029010643 @default.
• W2034704670 hasAuthorship W2034704670A5029140865 @default.
• W2034704670 hasAuthorship W2034704670A5044250695 @default.
• W2034704670 hasAuthorship W2034704670A5065500205 @default.
• W2034704670 hasAuthorship W2034704670A5071006316 @default.
• W2034704670 hasAuthorship W2034704670A5081810190 @default.
• W2034704670 hasAuthorship W2034704670A5086449835 @default.
• W2034704670 hasConcept C104317684 @default.
• W2034704670 hasConcept C109748351 @default.
• W2034704670 hasConcept C142724271 @default.
• W2034704670 hasConcept C143589142 @default.
• W2034704670 hasConcept C180754005 @default.
• W2034704670 hasConcept C190283241 @default.
• W2034704670 hasConcept C204232928 @default.
• W2034704670 hasConcept C2777609662 @default.
• W2034704670 hasConcept C2778227246 @default.
• W2034704670 hasConcept C2778264664 @default.
• W2034704670 hasConcept C2778880634 @default.
• W2034704670 hasConcept C2779142324 @default.
• W2034704670 hasConcept C30481170 @default.
• W2034704670 hasConcept C502942594 @default.
• W2034704670 hasConcept C53226629 @default.
• W2034704670 hasConcept C54355233 @default.
• W2034704670 hasConcept C555283112 @default.
• W2034704670 hasConcept C71924100 @default.
• W2034704670 hasConcept C86554907 @default.
• W2034704670 hasConcept C86803240 @default.
• W2034704670 hasConceptScore W2034704670C104317684 @default.
• W2034704670 hasConceptScore W2034704670C109748351 @default.
• W2034704670 hasConceptScore W2034704670C142724271 @default.
• W2034704670 hasConceptScore W2034704670C143589142 @default.
• W2034704670 hasConceptScore W2034704670C180754005 @default.
• W2034704670 hasConceptScore W2034704670C190283241 @default.
• W2034704670 hasConceptScore W2034704670C204232928 @default.
• W2034704670 hasConceptScore W2034704670C2777609662 @default.
• W2034704670 hasConceptScore W2034704670C2778227246 @default.
• W2034704670 hasConceptScore W2034704670C2778264664 @default.
• W2034704670 hasConceptScore W2034704670C2778880634 @default.
• W2034704670 hasConceptScore W2034704670C2779142324 @default.
• W2034704670 hasConceptScore W2034704670C30481170 @default.
• W2034704670 hasConceptScore W2034704670C502942594 @default.
• W2034704670 hasConceptScore W2034704670C53226629 @default.
• W2034704670 hasConceptScore W2034704670C54355233 @default.
• W2034704670 hasConceptScore W2034704670C555283112 @default.
• W2034704670 hasConceptScore W2034704670C71924100 @default.
• W2034704670 hasConceptScore W2034704670C86554907 @default.
• W2034704670 hasConceptScore W2034704670C86803240 @default.
• W2034704670 hasIssue "3" @default.
• W2034704670 hasLocation W20347046701 @default.
• W2034704670 hasLocation W20347046702 @default.
• W2034704670 hasOpenAccess W2034704670 @default.
• W2034704670 hasPrimaryLocation W20347046701 @default.
• W2034704670 hasRelatedWork W1536149736 @default.
• W2034704670 hasRelatedWork W1990389893 @default.
• W2034704670 hasRelatedWork W2000749236 @default.
• W2034704670 hasRelatedWork W2037385288 @default.
• W2034704670 hasRelatedWork W2084266051 @default.

• next