Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034705099> ?p ?o ?g. }
- W2034705099 endingPage "1165" @default.
- W2034705099 startingPage "1144" @default.
- W2034705099 abstract "GcvB is one of the most highly conserved Hfq-associated small RNAs in Gram-negative bacteria and was previously reported to repress several ABC transporters for amino acids. To determine the full extent of GcvB-mediated regulation in Salmonella, we combined a genome-wide experimental approach with biocomputational target prediction. Comparative pulse expression of wild-type versus mutant sRNA variants revealed that GcvB governs a large post-transcriptional regulon, impacting ~1% of all Salmonella genes via its conserved G/U-rich domain R1. Complementary predictions of C/A-rich binding sites in mRNAs and gfp reporter fusion experiments increased the number of validated GcvB targets to more than 20, and doubled the number of regulated amino acid transporters. Unlike the previously described targeting via the single R1 domain, GcvB represses the glycine transporter CycA by exceptionally redundant base-pairing. This novel ability of GcvB is focused upon the one target that could feedback-regulate the glycine-responsive synthesis of GcvB. Several newly discovered mRNA targets involved in amino acid metabolism, including the global regulator Lrp, question the previous assumption that GcvB simply acts to limit unnecessary amino acid uptake. Rather, GcvB rewires primary transcriptional control circuits and seems to act as a distinct regulatory node in amino acid metabolism." @default.
- W2034705099 created "2016-06-24" @default.
- W2034705099 creator A5013530445 @default.
- W2034705099 creator A5023277908 @default.
- W2034705099 creator A5024513852 @default.
- W2034705099 creator A5037571507 @default.
- W2034705099 creator A5048266578 @default.
- W2034705099 creator A5060415677 @default.
- W2034705099 date "2011-07-27" @default.
- W2034705099 modified "2023-10-02" @default.
- W2034705099 title "Pervasive post-transcriptional control of genes involved in amino acid metabolism by the Hfq-dependent GcvB small RNA" @default.
- W2034705099 cites W1518596802 @default.
- W2034705099 cites W1519401349 @default.
- W2034705099 cites W1522258613 @default.
- W2034705099 cites W1538375169 @default.
- W2034705099 cites W1579160232 @default.
- W2034705099 cites W1585733340 @default.
- W2034705099 cites W1625101491 @default.
- W2034705099 cites W1637929459 @default.
- W2034705099 cites W1648497775 @default.
- W2034705099 cites W1817610629 @default.
- W2034705099 cites W1888268148 @default.
- W2034705099 cites W1938034723 @default.
- W2034705099 cites W1951876147 @default.
- W2034705099 cites W1967924074 @default.
- W2034705099 cites W1972312133 @default.
- W2034705099 cites W1980585256 @default.
- W2034705099 cites W1982658095 @default.
- W2034705099 cites W1988717370 @default.
- W2034705099 cites W1989534009 @default.
- W2034705099 cites W1990477056 @default.
- W2034705099 cites W1995907648 @default.
- W2034705099 cites W1997433215 @default.
- W2034705099 cites W1998137451 @default.
- W2034705099 cites W1999339753 @default.
- W2034705099 cites W1999530403 @default.
- W2034705099 cites W2003550923 @default.
- W2034705099 cites W2004308966 @default.
- W2034705099 cites W2005008281 @default.
- W2034705099 cites W2006258345 @default.
- W2034705099 cites W2014372073 @default.
- W2034705099 cites W2016481001 @default.
- W2034705099 cites W2017492242 @default.
- W2034705099 cites W2026856977 @default.
- W2034705099 cites W2028102516 @default.
- W2034705099 cites W2029316600 @default.
- W2034705099 cites W2031128449 @default.
- W2034705099 cites W2033971197 @default.
- W2034705099 cites W2044747367 @default.
- W2034705099 cites W2045378165 @default.
- W2034705099 cites W2061673063 @default.
- W2034705099 cites W2063855430 @default.
- W2034705099 cites W2066369165 @default.
- W2034705099 cites W2072422539 @default.
- W2034705099 cites W2073793435 @default.
- W2034705099 cites W2076696121 @default.
- W2034705099 cites W2078797908 @default.
- W2034705099 cites W2083826871 @default.
- W2034705099 cites W2088784401 @default.
- W2034705099 cites W2097269978 @default.
- W2034705099 cites W2100959904 @default.
- W2034705099 cites W2101153968 @default.
- W2034705099 cites W2102263295 @default.
- W2034705099 cites W2105495135 @default.
- W2034705099 cites W2112178731 @default.
- W2034705099 cites W2113042773 @default.
- W2034705099 cites W2119338907 @default.
- W2034705099 cites W2119538428 @default.
- W2034705099 cites W2122669252 @default.
- W2034705099 cites W2122800479 @default.
- W2034705099 cites W2128569683 @default.
- W2034705099 cites W2132304324 @default.
- W2034705099 cites W2132848412 @default.
- W2034705099 cites W2134412337 @default.
- W2034705099 cites W2136989315 @default.
- W2034705099 cites W2137293271 @default.
- W2034705099 cites W2137491597 @default.
- W2034705099 cites W2137677639 @default.
- W2034705099 cites W2139023014 @default.
- W2034705099 cites W2139271133 @default.
- W2034705099 cites W2142136966 @default.
- W2034705099 cites W2146165665 @default.
- W2034705099 cites W2147773138 @default.
- W2034705099 cites W2148277388 @default.
- W2034705099 cites W2150264499 @default.
- W2034705099 cites W2150882562 @default.
- W2034705099 cites W2156544370 @default.
- W2034705099 cites W2163312119 @default.
- W2034705099 cites W2166429423 @default.
- W2034705099 cites W2167007274 @default.
- W2034705099 cites W2170817126 @default.
- W2034705099 cites W2255235260 @default.
- W2034705099 cites W4230004685 @default.
- W2034705099 doi "https://doi.org/10.1111/j.1365-2958.2011.07751.x" @default.
- W2034705099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21696468" @default.
- W2034705099 hasPublicationYear "2011" @default.
- W2034705099 type Work @default.
- W2034705099 sameAs 2034705099 @default.