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• W2034705390 abstract "Titration of the single dissociable proton in phosphatidylglycerol bilayers not only shifts the ordered-fluid phase transition but also changes the bilayer fluidity in the region above the phase transition, and gives rise to a quite different bilayer structure in the region below the phase transition: 1. The ordered-fluid phase transition temperatures of dimyristoyl and dipalmitoyl phosphatidylglycerol bilayers have been measured as a function of bulk pH in 0.1 M salt using water-lipid partitioning spin labels. From the dissociation curve obtained, it is found that the one titrable proton has an apparent pKa of 2.9 for bilayers of both lipids. 2. In the fully ionized state, these phosphatidylglycerols not only give very similar transition temperatures (23°C for dimyristoyl and 40°C for dipalmitoyl chains) and pre-transition temperatures to the similar chain length phosphatidylcholines, but also show identical bilayer structures at corresponding temperatures when examined by freeze-fracture electron microscopy: i.e. defects, ripples and jumbled patterns, in the ordered, pre-transitional and fluid phases, respectively. 3. When the phosphatidylglycerols are fully protonated, the bilayer pre-transition, as monitored by the spin labels, is absent and the main transition is somewhat broader and increased in temperature by approx. 17°C. Exclusively smooth bilayers are observed by electron microscopy at all temperatures. This suggests that, contrary to the situation in the charged bilayers, the phosphatidylglycerol molecules are not tilted relative to the bilayer normal in the ordered phase. 4. In fluid bilayers, above the main transition temperature, the fluidity is found to be greater when the phosphatidylglycerol molecules are charged than when uncharged, due to the increased intermolecular separation caused by electrostatic repulsion. The results demonstrate that the structure and fluidity of charged lipid bilayer membranes can be changed isothermally without the mediation of the ordered-fluid phase transition." @default.
• W2034705390 created "2016-06-24" @default.
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• W2034705390 date "1978-06-01" @default.
• W2034705390 modified "2023-09-27" @default.
• W2034705390 title "Control of the structure and fluidity of phosphatidylglycerol bilayers by pH titration" @default.
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• W2034705390 doi "https://doi.org/10.1016/0005-2736(78)90130-x" @default.
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