FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034706078> ?p ?o ?g. }

• W2034706078 endingPage "30" @default.
• W2034706078 startingPage "19" @default.
• W2034706078 abstract "Recent studies indicate that there is a marked reduction in trkA-containing nucleus basalis neurons in end-stage Alzheimer's disease (AD). We used unbiased stereological counting procedures to determine whether these changes extend to individuals with mild cognitive impairment (MCI) without dementia from a cohort of people enrolled in the Religious Orders Study. Thirty people (average age 84.7 years) came to autopsy. All individuals were cognitively tested within 12 months of death (average MMSE 24.2). Clinically, 9 had no cognitive impairment (NCI), 12 were categorized with MCI, and 9 had probable AD The average number of trkA-immunoreactive neurons in persons with NCI was 196, 632 +/- 12,093 (n = 9), for those with MCI it was 106,110 +/- 14,565, and for those with AD it was 86,978 +/- 12,141. Multiple comparisons showed that both those with MCI and those with AD had significant loss in the number of trkA-containing neurons compared to those with NCI (46% decrease for MCI, 56% for AD). An analysis of variance revealed that the total number of neurons containing trkA immunoreactivity was related to diagnostic classification (P < 0.001), with a significant reduction in AD and MCI compared to NCI but without a significant difference between MCI and AD. Cell density was similarly related to diagnostic classification (P < 0.001). There was a significant correlation with the Boston Naming Test and with a global score measure of cognitive function. The number of trkA-immunoreactive neurons was not correlated with MMSE, age at death, education, apolipoprotein E allele status, gender, or Braak score. These data indicate that alterations in the number of nucleus basalis neurons containing trkA immunoreactivity occurs early and are not accelerated from the transition from MCI to mild AD." @default.
• W2034706078 created "2016-06-24" @default.
• W2034706078 creator A5000179437 @default.
• W2034706078 creator A5002907434 @default.
• W2034706078 creator A5014075642 @default.
• W2034706078 creator A5044849434 @default.
• W2034706078 creator A5069078479 @default.
• W2034706078 creator A5072527270 @default.
• W2034706078 creator A5074765508 @default.
• W2034706078 creator A5089160266 @default.
• W2034706078 date "2000-01-01" @default.
• W2034706078 modified "2023-09-29" @default.
• W2034706078 title "Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease" @default.
• W2034706078 cites W1539302044 @default.
• W2034706078 cites W1569576869 @default.
• W2034706078 cites W1638939027 @default.
• W2034706078 cites W1847168837 @default.
• W2034706078 cites W1964329978 @default.
• W2034706078 cites W1966377606 @default.
• W2034706078 cites W1968892572 @default.
• W2034706078 cites W1969534573 @default.
• W2034706078 cites W1974539706 @default.
• W2034706078 cites W1974607544 @default.
• W2034706078 cites W1975505777 @default.
• W2034706078 cites W1979968933 @default.
• W2034706078 cites W1980657066 @default.
• W2034706078 cites W1989592528 @default.
• W2034706078 cites W1990073151 @default.
• W2034706078 cites W1994067502 @default.
• W2034706078 cites W1994431913 @default.
• W2034706078 cites W1995261715 @default.
• W2034706078 cites W1995514071 @default.
• W2034706078 cites W1998925703 @default.
• W2034706078 cites W1999667056 @default.
• W2034706078 cites W2001342433 @default.
• W2034706078 cites W2002496882 @default.
• W2034706078 cites W2003109983 @default.
• W2034706078 cites W2005780620 @default.
• W2034706078 cites W2005890826 @default.
• W2034706078 cites W2008180577 @default.
• W2034706078 cites W2011474174 @default.
• W2034706078 cites W2013486109 @default.
• W2034706078 cites W2013854477 @default.
• W2034706078 cites W2015795476 @default.
• W2034706078 cites W2017877656 @default.
• W2034706078 cites W2024927390 @default.
• W2034706078 cites W2025543844 @default.
• W2034706078 cites W2025894278 @default.
• W2034706078 cites W2026709325 @default.
• W2034706078 cites W2028087867 @default.
• W2034706078 cites W2030163298 @default.
• W2034706078 cites W2032098659 @default.
• W2034706078 cites W2037171234 @default.
• W2034706078 cites W2046931510 @default.
• W2034706078 cites W2048809344 @default.
• W2034706078 cites W2049100671 @default.
• W2034706078 cites W2052261143 @default.
• W2034706078 cites W2052375344 @default.
• W2034706078 cites W2052742260 @default.
• W2034706078 cites W2054814754 @default.
• W2034706078 cites W205551527 @default.
• W2034706078 cites W2058059749 @default.
• W2034706078 cites W2059434882 @default.
• W2034706078 cites W2062002803 @default.
• W2034706078 cites W2062267403 @default.
• W2034706078 cites W2062706679 @default.
• W2034706078 cites W2066093836 @default.
• W2034706078 cites W2068501914 @default.
• W2034706078 cites W2069482942 @default.
• W2034706078 cites W2072150523 @default.
• W2034706078 cites W2072691846 @default.
• W2034706078 cites W2075625163 @default.
• W2034706078 cites W2076433885 @default.
• W2034706078 cites W2078626049 @default.
• W2034706078 cites W2079749027 @default.
• W2034706078 cites W2087671869 @default.
• W2034706078 cites W2093374391 @default.
• W2034706078 cites W2093645050 @default.
• W2034706078 cites W2100271408 @default.
• W2034706078 cites W2104227586 @default.
• W2034706078 cites W2105382539 @default.
• W2034706078 cites W2107983005 @default.
• W2034706078 cites W2111493525 @default.
• W2034706078 cites W2118357539 @default.
• W2034706078 cites W2119376552 @default.
• W2034706078 cites W2146729934 @default.
• W2034706078 cites W2156220037 @default.
• W2034706078 cites W2158598336 @default.
• W2034706078 cites W2158766477 @default.
• W2034706078 cites W2497685916 @default.
• W2034706078 cites W4231438014 @default.
• W2034706078 cites W4253459895 @default.
• W2034706078 cites W4301136144 @default.
• W2034706078 doi "https://doi.org/10.1002/1096-9861(20001106)427:1<19::aid-cne2>3.0.co;2-a" @default.
• W2034706078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11042589" @default.
• W2034706078 hasPublicationYear "2000" @default.
• W2034706078 type Work @default.
• W2034706078 sameAs 2034706078 @default.

• next