FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034706088> ?p ?o ?g. }

• W2034706088 endingPage "212" @default.
• W2034706088 startingPage "205" @default.
• W2034706088 abstract "There is a concern that chemicals in our environment are affecting human health by disrupting normal endocrine function. Much of the concern has focused on chemicals that can interact directly with steroid hormone receptors. We have used a yeast-based assay to assess chemical interactions with the estrogen, androgen, and progesterone receptors. The yeast transformants used in this study contained the human estrogen, androgen, or progesterone receptor along with the appropriate steroid responsive elements upstream of the β-galactosidase reporter gene. Chemicals were added to yeast cultures in doses ranging from 10−12to 10−4mand following incubation, the yeasts were then lysed and assayed for β-galactosidase activity. Diethylstilbesterol and 17-β estradiol were most active in the estrogen receptor assay, followed by the phytoestrogen, coumestrol.p-Nonylphenol and bisphenol A were approximately 5000- and 15,000-fold less active, respectively, than estradiol. Methoxychlor, DDT and its metabolites,o,p′-DDD, ando,p′-DDE ranged in potency from 5 to 24 × 106less potent than estradiol. Testosterone and dihydrotestosterone were most potent in the androgen receptor assay, followed by estradiol and progesterone.p,p′-DDE was approximately 106-fold less potent than testosterone. None of the industrial chemicals tested interacted with the progesterone receptor. These data demonstrate the utility of using yeast-based receptor assays for detecting chemical interaction with steroid receptors and these assays should serve as a useful component of anin vitro–in vivostrategy to assess the effects of chemicals on endocrine function." @default.
• W2034706088 created "2016-06-24" @default.
• W2034706088 creator A5012704180 @default.
• W2034706088 creator A5037201375 @default.
• W2034706088 creator A5041813906 @default.
• W2034706088 creator A5046200744 @default.
• W2034706088 creator A5053150952 @default.
• W2034706088 creator A5054471172 @default.
• W2034706088 creator A5062055452 @default.
• W2034706088 date "1997-03-01" @default.
• W2034706088 modified "2023-09-27" @default.
• W2034706088 title "Evaluation of Chemicals with Endocrine Modulating Activity in a Yeast-Based Steroid Hormone Receptor Gene Transcription Assay" @default.
• W2034706088 cites W124024246 @default.
• W2034706088 cites W1509081656 @default.
• W2034706088 cites W1545204276 @default.
• W2034706088 cites W1551123135 @default.
• W2034706088 cites W1966534090 @default.
• W2034706088 cites W1973782344 @default.
• W2034706088 cites W1979439941 @default.
• W2034706088 cites W1987099303 @default.
• W2034706088 cites W1988474964 @default.
• W2034706088 cites W1992280932 @default.
• W2034706088 cites W1994976609 @default.
• W2034706088 cites W2002021255 @default.
• W2034706088 cites W2007048730 @default.
• W2034706088 cites W2009040345 @default.
• W2034706088 cites W2009548582 @default.
• W2034706088 cites W2018617566 @default.
• W2034706088 cites W2023690921 @default.
• W2034706088 cites W2024997214 @default.
• W2034706088 cites W2031390952 @default.
• W2034706088 cites W2038523027 @default.
• W2034706088 cites W2040664203 @default.
• W2034706088 cites W2042298854 @default.
• W2034706088 cites W2052203027 @default.
• W2034706088 cites W2053497689 @default.
• W2034706088 cites W2061947638 @default.
• W2034706088 cites W2066113503 @default.
• W2034706088 cites W2066503178 @default.
• W2034706088 cites W2066570340 @default.
• W2034706088 cites W2067589028 @default.
• W2034706088 cites W2073547442 @default.
• W2034706088 cites W2077815818 @default.
• W2034706088 cites W2078740994 @default.
• W2034706088 cites W2095161900 @default.
• W2034706088 cites W2097371988 @default.
• W2034706088 cites W2101512112 @default.
• W2034706088 cites W2106162177 @default.
• W2034706088 cites W2106519485 @default.
• W2034706088 cites W2106972325 @default.
• W2034706088 cites W2110992142 @default.
• W2034706088 cites W2118057169 @default.
• W2034706088 cites W2118359480 @default.
• W2034706088 cites W2127276770 @default.
• W2034706088 cites W2132929798 @default.
• W2034706088 cites W2143669170 @default.
• W2034706088 cites W2144551073 @default.
• W2034706088 cites W2155325209 @default.
• W2034706088 cites W2169333620 @default.
• W2034706088 cites W4254568758 @default.
• W2034706088 doi "https://doi.org/10.1006/taap.1996.8069" @default.
• W2034706088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9073609" @default.
• W2034706088 hasPublicationYear "1997" @default.
• W2034706088 type Work @default.
• W2034706088 sameAs 2034706088 @default.
• W2034706088 citedByCount "625" @default.
• W2034706088 countsByYear W20347060882012 @default.
• W2034706088 countsByYear W20347060882013 @default.
• W2034706088 countsByYear W20347060882014 @default.
• W2034706088 countsByYear W20347060882015 @default.
• W2034706088 countsByYear W20347060882016 @default.
• W2034706088 countsByYear W20347060882017 @default.
• W2034706088 countsByYear W20347060882018 @default.
• W2034706088 countsByYear W20347060882019 @default.
• W2034706088 countsByYear W20347060882020 @default.
• W2034706088 countsByYear W20347060882021 @default.
• W2034706088 countsByYear W20347060882022 @default.
• W2034706088 countsByYear W20347060882023 @default.
• W2034706088 crossrefType "journal-article" @default.
• W2034706088 hasAuthorship W2034706088A5012704180 @default.
• W2034706088 hasAuthorship W2034706088A5037201375 @default.
• W2034706088 hasAuthorship W2034706088A5041813906 @default.
• W2034706088 hasAuthorship W2034706088A5046200744 @default.
• W2034706088 hasAuthorship W2034706088A5053150952 @default.
• W2034706088 hasAuthorship W2034706088A5054471172 @default.
• W2034706088 hasAuthorship W2034706088A5062055452 @default.
• W2034706088 hasConcept C104317684 @default.
• W2034706088 hasConcept C121608353 @default.
• W2034706088 hasConcept C126322002 @default.
• W2034706088 hasConcept C134018914 @default.
• W2034706088 hasConcept C150194340 @default.
• W2034706088 hasConcept C161733203 @default.
• W2034706088 hasConcept C170493617 @default.
• W2034706088 hasConcept C2776888042 @default.
• W2034706088 hasConcept C2777164284 @default.
• W2034706088 hasConcept C2777911890 @default.
• W2034706088 hasConcept C2778270713 @default.
• W2034706088 hasConcept C2778355148 @default.

• next