FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034706174> ?p ?o ?g. }

• W2034706174 endingPage "310" @default.
• W2034706174 startingPage "303" @default.
• W2034706174 abstract "Endometriosis is a common estrogen-dependent gynecological disease. In patients with endometriosis estradiol can be synthesized locally in the endometriotic lesions from inactive precursors of adrenal or ovarian origin, via the aromatase pathway. These increased estradiol levels stimulate proliferation of endometriotic tissue. The progestins have been used in the therapy of endometriosis for more than 40 years but their pharmacological action is still not understood in detail. In the present study we therefore aimed to evaluate the effects of three progestins most commonly used in the therapy of endometriosis; medroxyprogesterone acetate, dydrogesterone and dienogest on expression of all genes encoding enzymes of the aromatase pathway and estrogen receptors in the Z-12 model epithelial cell line of peritoneal endometriosis, by qPCR and Western blotting. Our results show that application of medroxyprogestrone acetate, dydrogesterone and dienogest significantly decreases HSD17B1 and CYP19A1 expression and significantly increases HSD17B2 expression. Dydrogesterone and dienogest also significantly suppress ESR1 and ESR2 transcription, whereas medroxyprogestrone acetate and dydrogesterone significantly reduce mRNA levels of GPER. Our results thus suggest that in peritoneal endometriosis the beneficial effects of these progestins can be explained by lower HSD17B1 and higher HSD17B2 mRNA and protein levels, which lead to reduced local E2 biosynthesis. Although progestins significantly decrease CYP19A1 mRNA levels, the protein itself was not detectable by Western blotting. As progestins down-regulate expression of ESR1, ESR2 and GPER, they might also prevent E2-mediated proliferation." @default.
• W2034706174 created "2016-06-24" @default.
• W2034706174 creator A5006745520 @default.
• W2034706174 creator A5040998934 @default.
• W2034706174 date "2012-11-01" @default.
• W2034706174 modified "2023-09-25" @default.
• W2034706174 title "Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line" @default.
• W2034706174 cites W1513717411 @default.
• W2034706174 cites W1577577364 @default.
• W2034706174 cites W1974214512 @default.
• W2034706174 cites W1975047209 @default.
• W2034706174 cites W1993354065 @default.
• W2034706174 cites W1995735732 @default.
• W2034706174 cites W2002208145 @default.
• W2034706174 cites W2027569417 @default.
• W2034706174 cites W2032301907 @default.
• W2034706174 cites W2032303470 @default.
• W2034706174 cites W2032505339 @default.
• W2034706174 cites W2050798820 @default.
• W2034706174 cites W2052591056 @default.
• W2034706174 cites W2059153388 @default.
• W2034706174 cites W2065466595 @default.
• W2034706174 cites W2081540072 @default.
• W2034706174 cites W2094997595 @default.
• W2034706174 cites W2097421553 @default.
• W2034706174 cites W2098917345 @default.
• W2034706174 cites W2116022066 @default.
• W2034706174 cites W2117221582 @default.
• W2034706174 cites W2127529986 @default.
• W2034706174 cites W2154880208 @default.
• W2034706174 cites W2159343696 @default.
• W2034706174 cites W2162323283 @default.
• W2034706174 cites W2163825655 @default.
• W2034706174 cites W2166974601 @default.
• W2034706174 cites W2168420558 @default.
• W2034706174 cites W2182124214 @default.
• W2034706174 cites W4211081176 @default.
• W2034706174 cites W4231488642 @default.
• W2034706174 cites W4236021943 @default.
• W2034706174 cites W4244575809 @default.
• W2034706174 cites W4248356941 @default.
• W2034706174 doi "https://doi.org/10.1016/j.jsbmb.2012.07.004" @default.
• W2034706174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22878119" @default.
• W2034706174 hasPublicationYear "2012" @default.
• W2034706174 type Work @default.
• W2034706174 sameAs 2034706174 @default.
• W2034706174 citedByCount "11" @default.
• W2034706174 countsByYear W20347061742013 @default.
• W2034706174 countsByYear W20347061742015 @default.
• W2034706174 countsByYear W20347061742017 @default.
• W2034706174 countsByYear W20347061742018 @default.
• W2034706174 countsByYear W20347061742019 @default.
• W2034706174 countsByYear W20347061742020 @default.
• W2034706174 countsByYear W20347061742021 @default.
• W2034706174 countsByYear W20347061742022 @default.
• W2034706174 countsByYear W20347061742023 @default.
• W2034706174 crossrefType "journal-article" @default.
• W2034706174 hasAuthorship W2034706174A5006745520 @default.
• W2034706174 hasAuthorship W2034706174A5040998934 @default.
• W2034706174 hasConcept C104317684 @default.
• W2034706174 hasConcept C121332964 @default.
• W2034706174 hasConcept C126322002 @default.
• W2034706174 hasConcept C134018914 @default.
• W2034706174 hasConcept C185592680 @default.
• W2034706174 hasConcept C2777164284 @default.
• W2034706174 hasConcept C2780791683 @default.
• W2034706174 hasConcept C54355233 @default.
• W2034706174 hasConcept C553450214 @default.
• W2034706174 hasConcept C55493867 @default.
• W2034706174 hasConcept C62520636 @default.
• W2034706174 hasConcept C71924100 @default.
• W2034706174 hasConcept C81885089 @default.
• W2034706174 hasConcept C86803240 @default.
• W2034706174 hasConcept C95444343 @default.
• W2034706174 hasConceptScore W2034706174C104317684 @default.
• W2034706174 hasConceptScore W2034706174C121332964 @default.
• W2034706174 hasConceptScore W2034706174C126322002 @default.
• W2034706174 hasConceptScore W2034706174C134018914 @default.
• W2034706174 hasConceptScore W2034706174C185592680 @default.
• W2034706174 hasConceptScore W2034706174C2777164284 @default.
• W2034706174 hasConceptScore W2034706174C2780791683 @default.
• W2034706174 hasConceptScore W2034706174C54355233 @default.
• W2034706174 hasConceptScore W2034706174C553450214 @default.
• W2034706174 hasConceptScore W2034706174C55493867 @default.
• W2034706174 hasConceptScore W2034706174C62520636 @default.
• W2034706174 hasConceptScore W2034706174C71924100 @default.
• W2034706174 hasConceptScore W2034706174C81885089 @default.
• W2034706174 hasConceptScore W2034706174C86803240 @default.
• W2034706174 hasConceptScore W2034706174C95444343 @default.
• W2034706174 hasIssue "3-5" @default.
• W2034706174 hasLocation W20347061741 @default.
• W2034706174 hasOpenAccess W2034706174 @default.
• W2034706174 hasPrimaryLocation W20347061741 @default.
• W2034706174 hasRelatedWork W1978736710 @default.
• W2034706174 hasRelatedWork W1986969712 @default.
• W2034706174 hasRelatedWork W1995050400 @default.
• W2034706174 hasRelatedWork W1995647897 @default.
• W2034706174 hasRelatedWork W2013481652 @default.

• next