FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034706269> ?p ?o ?g. }

• W2034706269 endingPage "26056" @default.
• W2034706269 startingPage "26038" @default.
• W2034706269 abstract "The cancer stem cell (CSC) model suggests that a small subpopulation of cancer cells possesses the ability to self-renew and give rise to malignant progeny that drive cancer progression. Recent reports have also proposed the existence of certain extra- or intracellular signals that allow cancer progenitors to dynamically revert to a stem cell state. However, the mechanisms underlying cancer cell plasticity and CSC expansion are not entirely clear. Our previous studies using a hyaluronan synthase 2 (Has2) transgenic mouse model demonstrated that hyaluronan overproduction caused rapid development of aggressive breast carcinoma at a high incidence. Thus, we hypothesize that hyaluronan overproduction may accelerate cancer progression by expanding CSC subpopulations during cancer development. Primary cancer cells were established from mammary tumors developed in the transgenic mice and subjected to the Hoechst 33342 dye exclusion assay to sort side population (SP) from non-side population (non-SP) cells. Flow cytometric analysis demonstrated the enrichment of CD44high/CD24low CSC-like cells in the SP fraction of hyaluronan-overproducing cancer cells. This subpopulation exhibited several characteristics that were similar to CSCs, including cancer-initiating and mammosphere-forming abilities. Excess hyaluronan production drove the epithelial-to-mesenchymal transition process defined as the loss of epithelial phenotypes, up-regulation of transforming growth factor β (TGF-β), and induction of the epithelial-to-mesenchymal transition-related transcriptional factors Snail and Twist. Inhibition of TGF-β-Snail signaling or silencing of Twist expression abrogated the entrance into a stem cell state. Taken together, our findings suggest that hyaluronan overproduction allows plastic cancer cell populations to revert to stem cell states via Twist and the TGF-β-Snail signaling axis. The cancer stem cell (CSC) model suggests that a small subpopulation of cancer cells possesses the ability to self-renew and give rise to malignant progeny that drive cancer progression. Recent reports have also proposed the existence of certain extra- or intracellular signals that allow cancer progenitors to dynamically revert to a stem cell state. However, the mechanisms underlying cancer cell plasticity and CSC expansion are not entirely clear. Our previous studies using a hyaluronan synthase 2 (Has2) transgenic mouse model demonstrated that hyaluronan overproduction caused rapid development of aggressive breast carcinoma at a high incidence. Thus, we hypothesize that hyaluronan overproduction may accelerate cancer progression by expanding CSC subpopulations during cancer development. Primary cancer cells were established from mammary tumors developed in the transgenic mice and subjected to the Hoechst 33342 dye exclusion assay to sort side population (SP) from non-side population (non-SP) cells. Flow cytometric analysis demonstrated the enrichment of CD44high/CD24low CSC-like cells in the SP fraction of hyaluronan-overproducing cancer cells. This subpopulation exhibited several characteristics that were similar to CSCs, including cancer-initiating and mammosphere-forming abilities. Excess hyaluronan production drove the epithelial-to-mesenchymal transition process defined as the loss of epithelial phenotypes, up-regulation of transforming growth factor β (TGF-β), and induction of the epithelial-to-mesenchymal transition-related transcriptional factors Snail and Twist. Inhibition of TGF-β-Snail signaling or silencing of Twist expression abrogated the entrance into a stem cell state. Taken together, our findings suggest that hyaluronan overproduction allows plastic cancer cell populations to revert to stem cell states via Twist and the TGF-β-Snail signaling axis." @default.
• W2034706269 created "2016-06-24" @default.
• W2034706269 creator A5000350608 @default.
• W2034706269 creator A5002779138 @default.
• W2034706269 creator A5034434439 @default.
• W2034706269 creator A5037855156 @default.
• W2034706269 creator A5047735202 @default.
• W2034706269 creator A5090591524 @default.
• W2034706269 date "2014-09-01" @default.
• W2034706269 modified "2023-10-18" @default.
• W2034706269 title "Excessive Hyaluronan Production Promotes Acquisition of Cancer Stem Cell Signatures through the Coordinated Regulation of Twist and the Transforming Growth Factor β (TGF-β)-Snail Signaling Axis" @default.
• W2034706269 cites W1557915717 @default.
• W2034706269 cites W1603168304 @default.
• W2034706269 cites W1976763025 @default.
• W2034706269 cites W1977903176 @default.
• W2034706269 cites W1987401325 @default.
• W2034706269 cites W1992804143 @default.
• W2034706269 cites W1996457889 @default.
• W2034706269 cites W1997476786 @default.
• W2034706269 cites W2010317454 @default.
• W2034706269 cites W2011599397 @default.
• W2034706269 cites W2012345757 @default.
• W2034706269 cites W2014629469 @default.
• W2034706269 cites W2014691022 @default.
• W2034706269 cites W2019627505 @default.
• W2034706269 cites W2023427658 @default.
• W2034706269 cites W2028324018 @default.
• W2034706269 cites W2028593825 @default.
• W2034706269 cites W2030699054 @default.
• W2034706269 cites W2031770999 @default.
• W2034706269 cites W2036008499 @default.
• W2034706269 cites W2039767026 @default.
• W2034706269 cites W2039825295 @default.
• W2034706269 cites W2043416876 @default.
• W2034706269 cites W2050775651 @default.
• W2034706269 cites W2062703811 @default.
• W2034706269 cites W2072228040 @default.
• W2034706269 cites W2073326952 @default.
• W2034706269 cites W2076585749 @default.
• W2034706269 cites W2084092470 @default.
• W2034706269 cites W2123937928 @default.
• W2034706269 cites W2124156632 @default.
• W2034706269 cites W2124846832 @default.
• W2034706269 cites W2132820593 @default.
• W2034706269 cites W2134203671 @default.
• W2034706269 cites W2136280424 @default.
• W2034706269 cites W2146267383 @default.
• W2034706269 cites W2146526923 @default.
• W2034706269 cites W2159433767 @default.
• W2034706269 cites W2159607376 @default.
• W2034706269 cites W2160655912 @default.
• W2034706269 cites W2167704983 @default.
• W2034706269 doi "https://doi.org/10.1074/jbc.m114.564120" @default.
• W2034706269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4176217" @default.
• W2034706269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25077968" @default.
• W2034706269 hasPublicationYear "2014" @default.
• W2034706269 type Work @default.
• W2034706269 sameAs 2034706269 @default.
• W2034706269 citedByCount "73" @default.
• W2034706269 countsByYear W20347062692015 @default.
• W2034706269 countsByYear W20347062692016 @default.
• W2034706269 countsByYear W20347062692017 @default.
• W2034706269 countsByYear W20347062692018 @default.
• W2034706269 countsByYear W20347062692019 @default.
• W2034706269 countsByYear W20347062692020 @default.
• W2034706269 countsByYear W20347062692021 @default.
• W2034706269 countsByYear W20347062692022 @default.
• W2034706269 countsByYear W20347062692023 @default.
• W2034706269 crossrefType "journal-article" @default.
• W2034706269 hasAuthorship W2034706269A5000350608 @default.
• W2034706269 hasAuthorship W2034706269A5002779138 @default.
• W2034706269 hasAuthorship W2034706269A5034434439 @default.
• W2034706269 hasAuthorship W2034706269A5037855156 @default.
• W2034706269 hasAuthorship W2034706269A5047735202 @default.
• W2034706269 hasAuthorship W2034706269A5090591524 @default.
• W2034706269 hasBestOaLocation W20347062691 @default.
• W2034706269 hasConcept C118131993 @default.
• W2034706269 hasConcept C121608353 @default.
• W2034706269 hasConcept C2779013556 @default.
• W2034706269 hasConcept C28328180 @default.
• W2034706269 hasConcept C2908647359 @default.
• W2034706269 hasConcept C502942594 @default.
• W2034706269 hasConcept C54355233 @default.
• W2034706269 hasConcept C55427017 @default.
• W2034706269 hasConcept C71924100 @default.
• W2034706269 hasConcept C76419328 @default.
• W2034706269 hasConcept C86803240 @default.
• W2034706269 hasConcept C95444343 @default.
• W2034706269 hasConcept C96232424 @default.
• W2034706269 hasConcept C99454951 @default.
• W2034706269 hasConceptScore W2034706269C118131993 @default.
• W2034706269 hasConceptScore W2034706269C121608353 @default.
• W2034706269 hasConceptScore W2034706269C2779013556 @default.
• W2034706269 hasConceptScore W2034706269C28328180 @default.
• W2034706269 hasConceptScore W2034706269C2908647359 @default.
• W2034706269 hasConceptScore W2034706269C502942594 @default.
• W2034706269 hasConceptScore W2034706269C54355233 @default.
• W2034706269 hasConceptScore W2034706269C55427017 @default.

• next