Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034708172> ?p ?o ?g. }
- W2034708172 endingPage "168" @default.
- W2034708172 startingPage "162" @default.
- W2034708172 abstract "In this study we investigated whether adipose-derived stem cells (ADSCs) had any beneficial protective effects on liver injury and regeneration in vivo. Moreover, we examined whether ADSCs protect hepatocytes via trophic molecules.We transplanted ADSCs into mice after 70% hepatectomy and ischemia-reperfusion, and observed liver injury and regeneration after reperfusion. We co-cultured hepatocytes with ADSCs using a Transwell system for 7 d and evaluated the viabilities of hepatocytes and the cytokine levels in the culture medium. Bevacizumab was used to confirm the effect of vascular endothelial growth factor (VEGF) on hepatocytes.ADSCs improved serum liver function at 6 h after reperfusion in a nonlethal model and stimulated liver regeneration at 24 h after reperfusion in a lethal model. VEGF levels in the culture medium were increased by co-culture ADSCs with hepatocytes. ADSCs improved the viabilities of hepatocytes. The inhibited production of VEGF by bevacizumab did not affect the viability of hepatocytes.ADSCs were able to ameliorate liver injury and stimulate liver regeneration in subsequent hepatectomy and ischemia-reperfusion-injured model mice. Furthermore, hepatocytes were protected by the trophic molecules of the ADSCs. However, such protective effects might be provided by mechanisms other than VEGF signaling." @default.
- W2034708172 created "2016-06-24" @default.
- W2034708172 creator A5004189291 @default.
- W2034708172 creator A5010934625 @default.
- W2034708172 creator A5019799614 @default.
- W2034708172 creator A5027440224 @default.
- W2034708172 creator A5030227876 @default.
- W2034708172 creator A5048946839 @default.
- W2034708172 creator A5051158483 @default.
- W2034708172 creator A5051832340 @default.
- W2034708172 creator A5054204391 @default.
- W2034708172 creator A5055604473 @default.
- W2034708172 date "2013-03-01" @default.
- W2034708172 modified "2023-09-25" @default.
- W2034708172 title "The protective effect of adipose-derived stem cells against liver injury by trophic molecules" @default.
- W2034708172 cites W1490154674 @default.
- W2034708172 cites W1597038591 @default.
- W2034708172 cites W1969281312 @default.
- W2034708172 cites W1972801443 @default.
- W2034708172 cites W1974323483 @default.
- W2034708172 cites W1982384048 @default.
- W2034708172 cites W1983200743 @default.
- W2034708172 cites W1991218840 @default.
- W2034708172 cites W1994923567 @default.
- W2034708172 cites W1997432717 @default.
- W2034708172 cites W2003529103 @default.
- W2034708172 cites W2023643660 @default.
- W2034708172 cites W2030920153 @default.
- W2034708172 cites W2034383440 @default.
- W2034708172 cites W2045696456 @default.
- W2034708172 cites W2047016318 @default.
- W2034708172 cites W2050680285 @default.
- W2034708172 cites W2053221827 @default.
- W2034708172 cites W2053506074 @default.
- W2034708172 cites W2055569470 @default.
- W2034708172 cites W2056850633 @default.
- W2034708172 cites W2057932705 @default.
- W2034708172 cites W2062331471 @default.
- W2034708172 cites W2074000348 @default.
- W2034708172 cites W2082978494 @default.
- W2034708172 cites W2084557224 @default.
- W2034708172 cites W2087376092 @default.
- W2034708172 cites W2099035168 @default.
- W2034708172 cites W2104559100 @default.
- W2034708172 cites W2107503723 @default.
- W2034708172 cites W2123389370 @default.
- W2034708172 cites W2130527720 @default.
- W2034708172 cites W2133426555 @default.
- W2034708172 cites W2159999899 @default.
- W2034708172 cites W2165438231 @default.
- W2034708172 cites W2167325570 @default.
- W2034708172 cites W2173497140 @default.
- W2034708172 doi "https://doi.org/10.1016/j.jss.2012.10.009" @default.
- W2034708172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23117122" @default.
- W2034708172 hasPublicationYear "2013" @default.
- W2034708172 type Work @default.
- W2034708172 sameAs 2034708172 @default.
- W2034708172 citedByCount "22" @default.
- W2034708172 countsByYear W20347081722013 @default.
- W2034708172 countsByYear W20347081722014 @default.
- W2034708172 countsByYear W20347081722015 @default.
- W2034708172 countsByYear W20347081722016 @default.
- W2034708172 countsByYear W20347081722017 @default.
- W2034708172 countsByYear W20347081722018 @default.
- W2034708172 countsByYear W20347081722019 @default.
- W2034708172 countsByYear W20347081722020 @default.
- W2034708172 countsByYear W20347081722021 @default.
- W2034708172 countsByYear W20347081722022 @default.
- W2034708172 crossrefType "journal-article" @default.
- W2034708172 hasAuthorship W2034708172A5004189291 @default.
- W2034708172 hasAuthorship W2034708172A5010934625 @default.
- W2034708172 hasAuthorship W2034708172A5019799614 @default.
- W2034708172 hasAuthorship W2034708172A5027440224 @default.
- W2034708172 hasAuthorship W2034708172A5030227876 @default.
- W2034708172 hasAuthorship W2034708172A5048946839 @default.
- W2034708172 hasAuthorship W2034708172A5051158483 @default.
- W2034708172 hasAuthorship W2034708172A5051832340 @default.
- W2034708172 hasAuthorship W2034708172A5054204391 @default.
- W2034708172 hasAuthorship W2034708172A5055604473 @default.
- W2034708172 hasConcept C126322002 @default.
- W2034708172 hasConcept C141071460 @default.
- W2034708172 hasConcept C142724271 @default.
- W2034708172 hasConcept C159110652 @default.
- W2034708172 hasConcept C16685009 @default.
- W2034708172 hasConcept C167734588 @default.
- W2034708172 hasConcept C171056886 @default.
- W2034708172 hasConcept C171089720 @default.
- W2034708172 hasConcept C185592680 @default.
- W2034708172 hasConcept C2776637226 @default.
- W2034708172 hasConcept C2776795407 @default.
- W2034708172 hasConcept C2776909242 @default.
- W2034708172 hasConcept C2777025900 @default.
- W2034708172 hasConcept C2780114680 @default.
- W2034708172 hasConcept C28328180 @default.
- W2034708172 hasConcept C502942594 @default.
- W2034708172 hasConcept C541997718 @default.
- W2034708172 hasConcept C71924100 @default.
- W2034708172 hasConcept C86803240 @default.