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• W2034708924 startingPage "269" @default.
• W2034708924 abstract "The present study aimed to experimentally confirm that long-term alcohol drinking causes a high risk of oral and esophageal cancer in aldehyde dehydrogenase 2 (ALDH2)-deficient individuals. Aldh2 knockout mice, an animal model of ALDH2-deficiency, were treated with 8% ethanol for 14 months. Levels of acetaldehyde-derived DNA adducts were increased in esophagus, tongue and submandibular gland. Our finding that a lack of Aldh2 leads to more DNA damage after chronic ethanol treatment in mice supports epidemiological findings on the carcinogenicity of alcohol in ALDH2-deficient individuals who drink chronically." @default.
• W2034708924 created "2016-06-24" @default.
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• W2034708924 date "2012-03-15" @default.
• W2034708924 modified "2023-10-17" @default.
• W2034708924 title "The effect of ethanol on the formation of<i>N </i>₂-ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus" @default.
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• W2034708924 doi "https://doi.org/10.3109/1354750x.2012.666675" @default.
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