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• W2034709592 abstract "In Drosophila, two features of small interfering RNA (siRNA) structure--5' phosphates and 3' hydroxyls--are reported to be essential for RNA interference (RNAi). Here, we show that as in Drosophila, a 5' phosphate is required for siRNA function in human HeLa cells. In contrast, we find no evidence in flies or humans for a role in RNAi for the siRNA 3' hydroxyl group. Our in vitro data suggest that in both flies and mammals, each siRNA guides endonucleolytic cleavage of the target RNA at a single site. We conclude that the underlying mechanism of RNAi is conserved between flies and mammals and that RNA-dependent RNA polymerases are not required for RNAi in these organisms." @default.
• W2034709592 created "2016-06-24" @default.
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• W2034709592 date "2002-09-01" @default.
• W2034709592 modified "2023-10-12" @default.
• W2034709592 title "Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways" @default.
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• W2034709592 doi "https://doi.org/10.1016/s1097-2765(02)00651-2" @default.
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