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• W2034711065 endingPage "700" @default.
• W2034711065 startingPage "696" @default.
• W2034711065 abstract "Osteoprotegerin (OPG) is a soluble receptor for the Osteoprotegerin-Ligand (OPGL) which is expressed on osteoblasts and mediates the signal for osteoclast differentiation. In the present study we demonstrate that OPG mRNA levels in MG-63 cells are increased in a dose-dependent manner after 8 h of treatment with IL-1α (338±53% over control at 25 U/ml). Interleukin-6 (IL-6), under similar culture conditions, does not affect OPG mRNA levels. Time-course studies show that IL-1α (25 U/ml) causes a transient increase of OPG mRNA levels in MG-63 cells, peaking after 4 h of treatment. An increase of the OPG transcript occurs in hOB cells at 0,5 h which is still present after 24 h of IL-1α treatment. In MG-63 cells neither basal- nor IL-1α-induced OPG mRNA levels are altered by the translational inhibitor cycloheximide. These results suggest that expression of OPG in osteoblasts may be regulated by IL-1α." @default.
• W2034711065 created "2016-06-24" @default.
• W2034711065 creator A5009969822 @default.
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• W2034711065 date "1998-07-01" @default.
• W2034711065 modified "2023-09-27" @default.
• W2034711065 title "Osteoprotegerin mRNA Is Increased by Interleukin-1α in the Human Osteosarcoma Cell Line MG-63 and in Human Osteoblast-Like Cells" @default.
• W2034711065 cites W1704134691 @default.
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• W2034711065 doi "https://doi.org/10.1006/bbrc.1998.9035" @default.
• W2034711065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9703989" @default.
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