Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034715145> ?p ?o ?g. }
- W2034715145 endingPage "635" @default.
- W2034715145 startingPage "631" @default.
- W2034715145 abstract "BACKGROUND Octreotide and terlipressin are widely used in acute variceal hemorrhage to reduce the bleeding rate. They purportedly act by mesenteric arterial vasoconstriction, thus reducing portal venous flow (PVF) and portal pressure. Little is known about the immediate-early hemodynamic effects of these drugs. AIM To compare the acute hemodynamic effects of octreotide and terlipressin in patients with cirrhosis. PATIENTS Forty-two cirrhotic patients with a history of variceal bleeding were randomized to receive either octreotide 100 μg intravenous bolus followed by a continuous infusion at 250 μg/h (n = 21), or terlipressin 2 mg intravenous bolus (n = 21). METHODS Mean arterial pressure (MAP), heart rate (HR), hepatic venous pressure gradient (HVPG), and PVF, assessed by duplex Doppler ultrasonography, were measured before and at 1, 5, 10, 15, 20, and 25 min after the start of drug administration. RESULTS Octreotide markedly decreased HVPG (−44.5 ± 17.8%) and PVF (−30.6 ± 13.6%) compared to the baseline at 1 min (p < 0.05). Thereafter, both variables rapidly returned toward the baseline, and by 5 min, no significant differences in HVPG (−7.1 ± 28.9%) and PVF (10.2 ± 26.2%) were noted. A similar transient effect on MAP and HR was observed. Terlipressin significantly decreased HVPG (−18.3 ± 11.9%) and PVF (−32.6 ± 10.5%) at 1 min (p < 0.05) and sustained these effects at all time points. The effects on arterial pressure and HR were also sustained. CONCLUSIONS Octreotide only transiently reduced portal pressure and flow, whereas the effects of terlipressin were sustained. These results suggest that terlipressin may have more sustained hemodynamic effects in patients with bleeding varices." @default.
- W2034715145 created "2016-06-24" @default.
- W2034715145 creator A5025716461 @default.
- W2034715145 creator A5040155349 @default.
- W2034715145 creator A5042678528 @default.
- W2034715145 creator A5043678761 @default.
- W2034715145 creator A5045202685 @default.
- W2034715145 creator A5046121537 @default.
- W2034715145 creator A5049691954 @default.
- W2034715145 creator A5052617482 @default.
- W2034715145 creator A5072555986 @default.
- W2034715145 creator A5075088268 @default.
- W2034715145 creator A5086709788 @default.
- W2034715145 date "2005-03-01" @default.
- W2034715145 modified "2023-10-17" @default.
- W2034715145 title "Acute Hemodynamic Effects of Octreotide and Terlipressin in Patients with Cirrhosis: A Randomized Comparison" @default.
- W2034715145 cites W1654091726 @default.
- W2034715145 cites W1798628354 @default.
- W2034715145 cites W1970828249 @default.
- W2034715145 cites W1970924425 @default.
- W2034715145 cites W1974669900 @default.
- W2034715145 cites W1977880159 @default.
- W2034715145 cites W1981721110 @default.
- W2034715145 cites W1986261009 @default.
- W2034715145 cites W1993103016 @default.
- W2034715145 cites W1997157661 @default.
- W2034715145 cites W2026204848 @default.
- W2034715145 cites W2028855083 @default.
- W2034715145 cites W2031248624 @default.
- W2034715145 cites W2032323546 @default.
- W2034715145 cites W2033922818 @default.
- W2034715145 cites W2034702464 @default.
- W2034715145 cites W2046700466 @default.
- W2034715145 cites W2057170535 @default.
- W2034715145 cites W2060203155 @default.
- W2034715145 cites W2061331348 @default.
- W2034715145 cites W2071658009 @default.
- W2034715145 cites W2071690367 @default.
- W2034715145 cites W2077949433 @default.
- W2034715145 cites W2124318864 @default.
- W2034715145 cites W2138560788 @default.
- W2034715145 cites W2168352227 @default.
- W2034715145 cites W2339736887 @default.
- W2034715145 cites W4239374680 @default.
- W2034715145 cites W4254238131 @default.
- W2034715145 cites W4255323393 @default.
- W2034715145 cites W4256311465 @default.
- W2034715145 cites W4300881100 @default.
- W2034715145 doi "https://doi.org/10.1111/j.1572-0241.2005.41381.x" @default.
- W2034715145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15743362" @default.
- W2034715145 hasPublicationYear "2005" @default.
- W2034715145 type Work @default.
- W2034715145 sameAs 2034715145 @default.
- W2034715145 citedByCount "106" @default.
- W2034715145 countsByYear W20347151452012 @default.
- W2034715145 countsByYear W20347151452013 @default.
- W2034715145 countsByYear W20347151452014 @default.
- W2034715145 countsByYear W20347151452015 @default.
- W2034715145 countsByYear W20347151452016 @default.
- W2034715145 countsByYear W20347151452017 @default.
- W2034715145 countsByYear W20347151452018 @default.
- W2034715145 countsByYear W20347151452019 @default.
- W2034715145 countsByYear W20347151452020 @default.
- W2034715145 countsByYear W20347151452021 @default.
- W2034715145 countsByYear W20347151452022 @default.
- W2034715145 countsByYear W20347151452023 @default.
- W2034715145 crossrefType "journal-article" @default.
- W2034715145 hasAuthorship W2034715145A5025716461 @default.
- W2034715145 hasAuthorship W2034715145A5040155349 @default.
- W2034715145 hasAuthorship W2034715145A5042678528 @default.
- W2034715145 hasAuthorship W2034715145A5043678761 @default.
- W2034715145 hasAuthorship W2034715145A5045202685 @default.
- W2034715145 hasAuthorship W2034715145A5046121537 @default.
- W2034715145 hasAuthorship W2034715145A5049691954 @default.
- W2034715145 hasAuthorship W2034715145A5052617482 @default.
- W2034715145 hasAuthorship W2034715145A5072555986 @default.
- W2034715145 hasAuthorship W2034715145A5075088268 @default.
- W2034715145 hasAuthorship W2034715145A5086709788 @default.
- W2034715145 hasConcept C126322002 @default.
- W2034715145 hasConcept C178853913 @default.
- W2034715145 hasConcept C2776297358 @default.
- W2034715145 hasConcept C2776452961 @default.
- W2034715145 hasConcept C2776988256 @default.
- W2034715145 hasConcept C2777214474 @default.
- W2034715145 hasConcept C2777953023 @default.
- W2034715145 hasConcept C2778808290 @default.
- W2034715145 hasConcept C2779393834 @default.
- W2034715145 hasConcept C2781025020 @default.
- W2034715145 hasConcept C42219234 @default.
- W2034715145 hasConcept C43376680 @default.
- W2034715145 hasConcept C56900294 @default.
- W2034715145 hasConcept C71924100 @default.
- W2034715145 hasConcept C84393581 @default.
- W2034715145 hasConcept C90924648 @default.
- W2034715145 hasConceptScore W2034715145C126322002 @default.
- W2034715145 hasConceptScore W2034715145C178853913 @default.
- W2034715145 hasConceptScore W2034715145C2776297358 @default.
- W2034715145 hasConceptScore W2034715145C2776452961 @default.