FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034715973> ?p ?o ?g. }

• W2034715973 endingPage "294" @default.
• W2034715973 startingPage "283" @default.
• W2034715973 abstract "Delivering growth factors from bone-like mineral combines osteoinductivity with osteoconductivity. The effects of individual and sequential exposure of BMP-2 and FGF-2 on osteogenic differentiation, and their release from apatite were studied to design a dual delivery system. Bone marrow stromal cells were seeded on TCPS with the addition of FGF-2 (2.5, 10, 40 ng/ml) or BMP-2 (50, 150, 450 ng/ml) for 6 days. DNA content and osteogenic response were examined weekly for 3 weeks. FGF-2 increased DNA content; however, high concentrations of FGF-2 inhibited/delayed osteogenic differentiation, while a threshold concentration of BMP-2 was required for significant osteogenic enhancement. The sequence of delivery of BMP-2 (300 ng/ml) and FGF-2 (2.5 ng/ml) also had a significant impact on osteogenic differentiation. Delivery of FGF-2 followed by BMP-2 or delivery of BMP-2 followed by BMP-2 and FGF-2 enhanced osteogenic differentiation compared to the simultaneous delivery of both factors. Release of BMP-2 and FGF-2 from bone-like mineral was significantly affected by the concentration used during coprecipitation. BMP-2 also demonstrated a higher “burst” release compared to FGF-2. By integrating the results of the sequential delivery of BMP-2 and FGF-2 in solution, with the release of individual growth factors from mineral, an organic/inorganic delivery system based on coprecipitation can be designed for multiple biomolecules." @default.
• W2034715973 created "2016-06-24" @default.
• W2034715973 creator A5010354196 @default.
• W2034715973 creator A5063834421 @default.
• W2034715973 creator A5070160093 @default.
• W2034715973 date "2012-01-01" @default.
• W2034715973 modified "2023-09-25" @default.
• W2034715973 title "Effects of osteogenic growth factors on bone marrow stromal cell differentiation in a mineral-based delivery system" @default.
• W2034715973 cites W1966102091 @default.
• W2034715973 cites W1968707407 @default.
• W2034715973 cites W1973840148 @default.
• W2034715973 cites W1987184477 @default.
• W2034715973 cites W1991766367 @default.
• W2034715973 cites W1996707345 @default.
• W2034715973 cites W2001821470 @default.
• W2034715973 cites W2007564570 @default.
• W2034715973 cites W2008464583 @default.
• W2034715973 cites W2019096325 @default.
• W2034715973 cites W2019303269 @default.
• W2034715973 cites W2026288162 @default.
• W2034715973 cites W2028419771 @default.
• W2034715973 cites W2030913739 @default.
• W2034715973 cites W2031252651 @default.
• W2034715973 cites W2033436710 @default.
• W2034715973 cites W2039065761 @default.
• W2034715973 cites W2039618142 @default.
• W2034715973 cites W2052431279 @default.
• W2034715973 cites W2052726451 @default.
• W2034715973 cites W2056984915 @default.
• W2034715973 cites W2057888154 @default.
• W2034715973 cites W2061366232 @default.
• W2034715973 cites W2061700961 @default.
• W2034715973 cites W2071862112 @default.
• W2034715973 cites W2074215290 @default.
• W2034715973 cites W2077758359 @default.
• W2034715973 cites W2098799479 @default.
• W2034715973 cites W2109354605 @default.
• W2034715973 cites W2111415695 @default.
• W2034715973 cites W2125538936 @default.
• W2034715973 cites W2129737101 @default.
• W2034715973 cites W2131978756 @default.
• W2034715973 cites W2147776420 @default.
• W2034715973 cites W2148328620 @default.
• W2034715973 cites W2159272869 @default.
• W2034715973 cites W2160020631 @default.
• W2034715973 cites W2172914696 @default.
• W2034715973 doi "https://doi.org/10.1016/j.biomaterials.2011.09.052" @default.
• W2034715973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3208792" @default.
• W2034715973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22014945" @default.
• W2034715973 hasPublicationYear "2012" @default.
• W2034715973 type Work @default.
• W2034715973 sameAs 2034715973 @default.
• W2034715973 citedByCount "38" @default.
• W2034715973 countsByYear W20347159732012 @default.
• W2034715973 countsByYear W20347159732013 @default.
• W2034715973 countsByYear W20347159732014 @default.
• W2034715973 countsByYear W20347159732015 @default.
• W2034715973 countsByYear W20347159732016 @default.
• W2034715973 countsByYear W20347159732017 @default.
• W2034715973 countsByYear W20347159732019 @default.
• W2034715973 countsByYear W20347159732020 @default.
• W2034715973 countsByYear W20347159732021 @default.
• W2034715973 countsByYear W20347159732023 @default.
• W2034715973 crossrefType "journal-article" @default.
• W2034715973 hasAuthorship W2034715973A5010354196 @default.
• W2034715973 hasAuthorship W2034715973A5063834421 @default.
• W2034715973 hasAuthorship W2034715973A5070160093 @default.
• W2034715973 hasBestOaLocation W20347159732 @default.
• W2034715973 hasConcept C126322002 @default.
• W2034715973 hasConcept C136229726 @default.
• W2034715973 hasConcept C16930146 @default.
• W2034715973 hasConcept C170493617 @default.
• W2034715973 hasConcept C179104552 @default.
• W2034715973 hasConcept C185592680 @default.
• W2034715973 hasConcept C192562407 @default.
• W2034715973 hasConcept C198826908 @default.
• W2034715973 hasConcept C202751555 @default.
• W2034715973 hasConcept C203014093 @default.
• W2034715973 hasConcept C2776541429 @default.
• W2034715973 hasConcept C2776886416 @default.
• W2034715973 hasConcept C2780007613 @default.
• W2034715973 hasConcept C28737856 @default.
• W2034715973 hasConcept C30352789 @default.
• W2034715973 hasConcept C55493867 @default.
• W2034715973 hasConcept C71924100 @default.
• W2034715973 hasConcept C74373430 @default.
• W2034715973 hasConcept C86803240 @default.
• W2034715973 hasConcept C95444343 @default.
• W2034715973 hasConceptScore W2034715973C126322002 @default.
• W2034715973 hasConceptScore W2034715973C136229726 @default.
• W2034715973 hasConceptScore W2034715973C16930146 @default.
• W2034715973 hasConceptScore W2034715973C170493617 @default.
• W2034715973 hasConceptScore W2034715973C179104552 @default.
• W2034715973 hasConceptScore W2034715973C185592680 @default.
• W2034715973 hasConceptScore W2034715973C192562407 @default.
• W2034715973 hasConceptScore W2034715973C198826908 @default.
• W2034715973 hasConceptScore W2034715973C202751555 @default.
• W2034715973 hasConceptScore W2034715973C203014093 @default.

• next