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- W2034722372 abstract "The demonstration by Minot and Murphy 1 that the feeding of liver brings about complete remission in pernicious anemia led to the development of liver extracts of various types, of which that of Cohn and his associates 2 is most generally used. A search for the effective substance in liver led to partial purification of the material, but these more or less purified substances developed by Cohn and his associates 3 and by West and his associates 4 have proved too expensive to be practical in the treatment of pernicious anemia. To Gansslen 5 belongs the credit of having first prepared at moderate expense an extract of liver suitable for injection intramuscularly. He injected daily into the gluteal muscles 2 cc., equal in effect to from 200 to 400 Gm. of liver. Castle and Taylor 6 obtained a maximal response in reticulocytes from a single intravenous injection of the extract" @default.
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- W2034722372 date "1932-08-20" @default.
- W2034722372 modified "2023-09-27" @default.
- W2034722372 title "INJECTION OF LIVER EXTRACT IN THE TREATMENT OF PERNICIOUS ANEMIA" @default.
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- W2034722372 doi "https://doi.org/10.1001/jama.1932.02740600006003" @default.
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