FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034722578> ?p ?o ?g. }

• W2034722578 endingPage "451" @default.
• W2034722578 startingPage "445" @default.
• W2034722578 abstract "11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) behaves predominantly as an oxoreductase converting the receptor-inactive glucocorticoids to their active forms in vivo, while the type 2 isoform (11β-HSD2) possesses only dehydrogenase activity and inactivates cortisol in human or corticosterone in rat. We determined enzyme activity of 11β-HSD in rat lungs from fetus to adult, and examined whether 11β-HSD1 exists in alveolar type II cells, the most important site for the synthesis of pulmonary surfactant in mature lungs, by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Enzyme activity of 11β-HSD1 and 2 in lung tissue homogenate were determined as NADP+- and NAD+-dependent conversion of corticosterone to 11-dehydrocorticosterone, respectively. We found that 11β-HSD1 activity was increased progressively from 21 days gestation to 7 weeks after birth. 11 β-HSD2 activity was significantly lower than that of 11β-HSD1 throughout gestation and after birth. Immunoreactivity for 11β-HSD1 was detected in the cytoplasm of the cells in the alveolar region of adult rats. Some of these expressing 11β-HSD1 were considered to be alveolar type II cells, because of their cuboid shape and localization at the corner of the alveoli. RT-PCR demonstrated 11 β-HSD1 mRNA in isolated alveolar type II cells. Our results suggest that alveolar type II cells enhance intracellular glucocorticoid availability via 11β-HSD1. 11β-HSD1 in alveolar type II cells is thought of as an autocrine amplifier of glucocorticoid action in the lung." @default.
• W2034722578 created "2016-06-24" @default.
• W2034722578 creator A5015575554 @default.
• W2034722578 creator A5020982275 @default.
• W2034722578 creator A5049751347 @default.
• W2034722578 creator A5053674042 @default.
• W2034722578 creator A5056179266 @default.
• W2034722578 creator A5063482458 @default.
• W2034722578 creator A5076262175 @default.
• W2034722578 date "2003-01-01" @default.
• W2034722578 modified "2023-10-16" @default.
• W2034722578 title "Expression of 11.BETA.-Hydroxysteroid Dehydrogenase Type 1 in Alveolar Epithelial Cells in Rats" @default.
• W2034722578 cites W1519525780 @default.
• W2034722578 cites W174043930 @default.
• W2034722578 cites W1975830768 @default.
• W2034722578 cites W1996973124 @default.
• W2034722578 cites W2012329129 @default.
• W2034722578 cites W2030191770 @default.
• W2034722578 cites W2078162308 @default.
• W2034722578 cites W2101439149 @default.
• W2034722578 cites W2119468663 @default.
• W2034722578 cites W2128635872 @default.
• W2034722578 cites W2129224957 @default.
• W2034722578 cites W2129306951 @default.
• W2034722578 cites W2148114970 @default.
• W2034722578 cites W2150925908 @default.
• W2034722578 cites W2243315189 @default.
• W2034722578 cites W2266715901 @default.
• W2034722578 cites W2419521861 @default.
• W2034722578 cites W4231927254 @default.
• W2034722578 cites W4233628548 @default.
• W2034722578 cites W4234029649 @default.
• W2034722578 cites W4238098326 @default.
• W2034722578 cites W4241837980 @default.
• W2034722578 cites W4247541414 @default.
• W2034722578 cites W4253157058 @default.
• W2034722578 cites W63938293 @default.
• W2034722578 doi "https://doi.org/10.1507/endocrj.50.445" @default.
• W2034722578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14599119" @default.
• W2034722578 hasPublicationYear "2003" @default.
• W2034722578 type Work @default.
• W2034722578 sameAs 2034722578 @default.
• W2034722578 citedByCount "12" @default.
• W2034722578 countsByYear W20347225782012 @default.
• W2034722578 countsByYear W20347225782014 @default.
• W2034722578 countsByYear W20347225782017 @default.
• W2034722578 countsByYear W20347225782021 @default.
• W2034722578 crossrefType "journal-article" @default.
• W2034722578 hasAuthorship W2034722578A5015575554 @default.
• W2034722578 hasAuthorship W2034722578A5020982275 @default.
• W2034722578 hasAuthorship W2034722578A5049751347 @default.
• W2034722578 hasAuthorship W2034722578A5053674042 @default.
• W2034722578 hasAuthorship W2034722578A5056179266 @default.
• W2034722578 hasAuthorship W2034722578A5063482458 @default.
• W2034722578 hasAuthorship W2034722578A5076262175 @default.
• W2034722578 hasBestOaLocation W20347225781 @default.
• W2034722578 hasConcept C126322002 @default.
• W2034722578 hasConcept C134018914 @default.
• W2034722578 hasConcept C153911025 @default.
• W2034722578 hasConcept C172680121 @default.
• W2034722578 hasConcept C181199279 @default.
• W2034722578 hasConcept C185592680 @default.
• W2034722578 hasConcept C2776317432 @default.
• W2034722578 hasConcept C2777714996 @default.
• W2034722578 hasConcept C2779234561 @default.
• W2034722578 hasConcept C2780352252 @default.
• W2034722578 hasConcept C2780841215 @default.
• W2034722578 hasConcept C54355233 @default.
• W2034722578 hasConcept C55493867 @default.
• W2034722578 hasConcept C59493245 @default.
• W2034722578 hasConcept C71315377 @default.
• W2034722578 hasConcept C71924100 @default.
• W2034722578 hasConcept C86803240 @default.
• W2034722578 hasConceptScore W2034722578C126322002 @default.
• W2034722578 hasConceptScore W2034722578C134018914 @default.
• W2034722578 hasConceptScore W2034722578C153911025 @default.
• W2034722578 hasConceptScore W2034722578C172680121 @default.
• W2034722578 hasConceptScore W2034722578C181199279 @default.
• W2034722578 hasConceptScore W2034722578C185592680 @default.
• W2034722578 hasConceptScore W2034722578C2776317432 @default.
• W2034722578 hasConceptScore W2034722578C2777714996 @default.
• W2034722578 hasConceptScore W2034722578C2779234561 @default.
• W2034722578 hasConceptScore W2034722578C2780352252 @default.
• W2034722578 hasConceptScore W2034722578C2780841215 @default.
• W2034722578 hasConceptScore W2034722578C54355233 @default.
• W2034722578 hasConceptScore W2034722578C55493867 @default.
• W2034722578 hasConceptScore W2034722578C59493245 @default.
• W2034722578 hasConceptScore W2034722578C71315377 @default.
• W2034722578 hasConceptScore W2034722578C71924100 @default.
• W2034722578 hasConceptScore W2034722578C86803240 @default.
• W2034722578 hasIssue "4" @default.
• W2034722578 hasLocation W20347225781 @default.
• W2034722578 hasLocation W20347225782 @default.
• W2034722578 hasOpenAccess W2034722578 @default.
• W2034722578 hasPrimaryLocation W20347225781 @default.
• W2034722578 hasRelatedWork W1756428141 @default.
• W2034722578 hasRelatedWork W2005344166 @default.
• W2034722578 hasRelatedWork W2015569104 @default.

• next