FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034724306> ?p ?o ?g. }

• W2034724306 endingPage "197" @default.
• W2034724306 startingPage "188" @default.
• W2034724306 abstract "Both constitutive and ligand-mediated membrane trafficking regulate Epidermal Growth Factor Receptor (EGFR) signaling. The constitutive endocytosis and recycling of the unliganded EGFR is a critical determinant of cell surface EGFR expression and the cell’s sensitivity to ligands. We report that two proteins with established roles in trafficking the EGF:EGFR complex to the lysosome also regulate the recycling of the unliganded EGFR. Knock down of either Tumor suppressor gene 101 (TSG101) or RAB7 causes the endosomal accumulation of the inactive, unliganded receptor in morphologically and biochemically distinct organelles. Knock down of TSG101 causes the EGFR to accumulate in low density endosomes whereas RAB7 knock down results in EGFR accumulation in high density endosomes. Knock down of either protein caused the receptor to co-localize primarily with LAMP-1, but not EEA1. These two proteins regulate EGFR slow, perinuclear recycling, via distinct mechanism and are new molecular targets that regulate cell surface EGFR expression." @default.
• W2034724306 created "2016-06-24" @default.
• W2034724306 creator A5009293705 @default.
• W2034724306 creator A5053273455 @default.
• W2034724306 date "2013-12-01" @default.
• W2034724306 modified "2023-10-16" @default.
• W2034724306 title "RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms" @default.
• W2034724306 cites W139613233 @default.
• W2034724306 cites W1489503277 @default.
• W2034724306 cites W1505339870 @default.
• W2034724306 cites W1587854090 @default.
• W2034724306 cites W1592646667 @default.
• W2034724306 cites W1669303234 @default.
• W2034724306 cites W2006501717 @default.
• W2034724306 cites W2027533965 @default.
• W2034724306 cites W2030153375 @default.
• W2034724306 cites W2030589581 @default.
• W2034724306 cites W2046416187 @default.
• W2034724306 cites W2049613194 @default.
• W2034724306 cites W2054735667 @default.
• W2034724306 cites W2064898884 @default.
• W2034724306 cites W2067376187 @default.
• W2034724306 cites W2072466401 @default.
• W2034724306 cites W2085263133 @default.
• W2034724306 cites W2085682841 @default.
• W2034724306 cites W2086824381 @default.
• W2034724306 cites W2095965043 @default.
• W2034724306 cites W2096287391 @default.
• W2034724306 cites W2106223472 @default.
• W2034724306 cites W2140759029 @default.
• W2034724306 cites W2143633028 @default.
• W2034724306 cites W2155274044 @default.
• W2034724306 cites W2159615155 @default.
• W2034724306 doi "https://doi.org/10.1016/j.mce.2013.07.029" @default.
• W2034724306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3831653" @default.
• W2034724306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23933150" @default.
• W2034724306 hasPublicationYear "2013" @default.
• W2034724306 type Work @default.
• W2034724306 sameAs 2034724306 @default.
• W2034724306 citedByCount "30" @default.
• W2034724306 countsByYear W20347243062014 @default.
• W2034724306 countsByYear W20347243062015 @default.
• W2034724306 countsByYear W20347243062016 @default.
• W2034724306 countsByYear W20347243062017 @default.
• W2034724306 countsByYear W20347243062018 @default.
• W2034724306 countsByYear W20347243062019 @default.
• W2034724306 countsByYear W20347243062020 @default.
• W2034724306 countsByYear W20347243062021 @default.
• W2034724306 countsByYear W20347243062022 @default.
• W2034724306 countsByYear W20347243062023 @default.
• W2034724306 crossrefType "journal-article" @default.
• W2034724306 hasAuthorship W2034724306A5009293705 @default.
• W2034724306 hasAuthorship W2034724306A5053273455 @default.
• W2034724306 hasBestOaLocation W20347243062 @default.
• W2034724306 hasConcept C102747710 @default.
• W2034724306 hasConcept C104317684 @default.
• W2034724306 hasConcept C127561419 @default.
• W2034724306 hasConcept C145059251 @default.
• W2034724306 hasConcept C1491633281 @default.
• W2034724306 hasConcept C170493617 @default.
• W2034724306 hasConcept C185592680 @default.
• W2034724306 hasConcept C20518536 @default.
• W2034724306 hasConcept C25602115 @default.
• W2034724306 hasConcept C2776362946 @default.
• W2034724306 hasConcept C2778283623 @default.
• W2034724306 hasConcept C2779438470 @default.
• W2034724306 hasConcept C28005876 @default.
• W2034724306 hasConcept C55493867 @default.
• W2034724306 hasConcept C79879829 @default.
• W2034724306 hasConcept C86803240 @default.
• W2034724306 hasConcept C95444343 @default.
• W2034724306 hasConceptScore W2034724306C102747710 @default.
• W2034724306 hasConceptScore W2034724306C104317684 @default.
• W2034724306 hasConceptScore W2034724306C127561419 @default.
• W2034724306 hasConceptScore W2034724306C145059251 @default.
• W2034724306 hasConceptScore W2034724306C1491633281 @default.
• W2034724306 hasConceptScore W2034724306C170493617 @default.
• W2034724306 hasConceptScore W2034724306C185592680 @default.
• W2034724306 hasConceptScore W2034724306C20518536 @default.
• W2034724306 hasConceptScore W2034724306C25602115 @default.
• W2034724306 hasConceptScore W2034724306C2776362946 @default.
• W2034724306 hasConceptScore W2034724306C2778283623 @default.
• W2034724306 hasConceptScore W2034724306C2779438470 @default.
• W2034724306 hasConceptScore W2034724306C28005876 @default.
• W2034724306 hasConceptScore W2034724306C55493867 @default.
• W2034724306 hasConceptScore W2034724306C79879829 @default.
• W2034724306 hasConceptScore W2034724306C86803240 @default.
• W2034724306 hasConceptScore W2034724306C95444343 @default.
• W2034724306 hasIssue "1-2" @default.
• W2034724306 hasLocation W20347243061 @default.
• W2034724306 hasLocation W20347243062 @default.
• W2034724306 hasLocation W20347243063 @default.
• W2034724306 hasLocation W20347243064 @default.
• W2034724306 hasOpenAccess W2034724306 @default.
• W2034724306 hasPrimaryLocation W20347243061 @default.
• W2034724306 hasRelatedWork W1973572007 @default.
• W2034724306 hasRelatedWork W2046416187 @default.
• W2034724306 hasRelatedWork W2109627615 @default.

• next