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- W2034726043 abstract "Publisher Summary This chapter discusses a study analyzing dopamine-β-hydroxylase (DBH) and the regulation of catecholamine biosynthesis. An enzymatic assay for DBH activity in tissue homogenates is used to study changes that occurred with pharmacologically induced alterations in sympathetic nervous system activity. This assay is based on the conversion of a β-hydroxylated product into its N-methyl derivative in the presence of radiolabeled S-adenosylmethionine. In this assay, either phenylethylamine or tyramine is converted into its β-hydroxylated product (phenylethanolamine or octopamine) by DBH in the presence of O2, ascorbate as an electron donor, and Cu2+ which is added to inactivate the endogenous inhibitors of DBH, which are present in nearly all tissues. The results of this study suggest that the long-term changes in the level of activity in the sympathetic nervous system result in changes in the amount of DBH in the neuron. These changes, like those observed with tyrosine hydroxylase (TH), appear to be mediated trans-synaptically and to require protein synthesis." @default.
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- W2034726043 date "1973-10-01" @default.
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- W2034726043 title "Dopamine β-hydroxylase and the regulation of catecholamine biosynthesis" @default.
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- W2034726043 doi "https://doi.org/10.1016/0024-3205(73)90098-2" @default.
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