Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034731698> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2034731698 endingPage "74" @default.
- W2034731698 startingPage "61" @default.
- W2034731698 abstract "Inborn errors of pyrimidine degradation, dihydropyrimidine dehydrogenase deficiency and dihydropyrimidinase deficiency, are less rare than has generally been assumed. Many asymptomatic cases have been reported, and in patients with symptoms, the clinical abnormalities are variable and nonspecific. Withdrawal of pyrimidine analogues such as 5-fluorouracil (5FU), a commonly used anticancer drug, from the cancer chemotherapy regimens of patients with pyrimidine degradation deficiencies, however, is critical because 5FU is degraded in vivo by pyrimidine-degradative enzymes. Patients with these deficiencies suffer from severe neurotoxicity, sometimes leading to death, following administration of 5FU, and even otherwise asymptomatic homozygotes or heterozygotes may develop severe clinical symptoms upon administration of such medication. Therefore, a rapid and specific method for identifying cancer patients with these enzyme deficiencies prior to treatment with 5FU is critical. To address this problem, we established methods for highly sensitive yet specific determinations of thymine, uracil, dihydrothymine, dihydrouracil, orotate and creatinine simultaneously in 0.1-ml liquid urine or filter-paper urine. This method involves stable isotope dilution, a simplified urease treatment previously described and gas chromatography-mass spectrometry without prior fractionation. The high recovery and low C.V. values were obtained and healthy control values were also determined for these metabolites. Using artificially prepared urine specimens simulating these disorders. the chemical diagnosis can be made clearly, and no further analysis appears to be required for differential chemical diagnosis." @default.
- W2034731698 created "2016-06-24" @default.
- W2034731698 creator A5025554083 @default.
- W2034731698 creator A5061424329 @default.
- W2034731698 creator A5080920020 @default.
- W2034731698 date "2001-07-01" @default.
- W2034731698 modified "2023-09-30" @default.
- W2034731698 title "Simple gas chromatographic–mass spectrometric procedure for diagnosing pyrimidine degradation defects for prevention of severe anticancer side effects" @default.
- W2034731698 cites W146076361 @default.
- W2034731698 cites W1483242733 @default.
- W2034731698 cites W1552036775 @default.
- W2034731698 cites W1567611583 @default.
- W2034731698 cites W1595259208 @default.
- W2034731698 cites W1924559684 @default.
- W2034731698 cites W1973745272 @default.
- W2034731698 cites W2031628758 @default.
- W2034731698 cites W2033085176 @default.
- W2034731698 cites W2038577032 @default.
- W2034731698 cites W2052149864 @default.
- W2034731698 cites W2053579443 @default.
- W2034731698 cites W2059326290 @default.
- W2034731698 cites W2077520632 @default.
- W2034731698 cites W2078030807 @default.
- W2034731698 cites W2100021150 @default.
- W2034731698 cites W2103109018 @default.
- W2034731698 cites W2115027526 @default.
- W2034731698 cites W2157830413 @default.
- W2034731698 cites W2185823732 @default.
- W2034731698 cites W2342238860 @default.
- W2034731698 cites W2396132185 @default.
- W2034731698 doi "https://doi.org/10.1016/s0378-4347(01)00143-8" @default.
- W2034731698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11482736" @default.
- W2034731698 hasPublicationYear "2001" @default.
- W2034731698 type Work @default.
- W2034731698 sameAs 2034731698 @default.
- W2034731698 citedByCount "23" @default.
- W2034731698 countsByYear W20347316982013 @default.
- W2034731698 countsByYear W20347316982016 @default.
- W2034731698 crossrefType "journal-article" @default.
- W2034731698 hasAuthorship W2034731698A5025554083 @default.
- W2034731698 hasAuthorship W2034731698A5061424329 @default.
- W2034731698 hasAuthorship W2034731698A5080920020 @default.
- W2034731698 hasConcept C123321153 @default.
- W2034731698 hasConcept C126322002 @default.
- W2034731698 hasConcept C181199279 @default.
- W2034731698 hasConcept C185592680 @default.
- W2034731698 hasConcept C200159599 @default.
- W2034731698 hasConcept C2776476023 @default.
- W2034731698 hasConcept C2776694085 @default.
- W2034731698 hasConcept C2776858809 @default.
- W2034731698 hasConcept C2777910003 @default.
- W2034731698 hasConcept C2778050828 @default.
- W2034731698 hasConcept C2779321679 @default.
- W2034731698 hasConcept C2779554091 @default.
- W2034731698 hasConcept C2780026642 @default.
- W2034731698 hasConcept C2780456651 @default.
- W2034731698 hasConcept C43617362 @default.
- W2034731698 hasConcept C552990157 @default.
- W2034731698 hasConcept C55493867 @default.
- W2034731698 hasConcept C71924100 @default.
- W2034731698 hasConceptScore W2034731698C123321153 @default.
- W2034731698 hasConceptScore W2034731698C126322002 @default.
- W2034731698 hasConceptScore W2034731698C181199279 @default.
- W2034731698 hasConceptScore W2034731698C185592680 @default.
- W2034731698 hasConceptScore W2034731698C200159599 @default.
- W2034731698 hasConceptScore W2034731698C2776476023 @default.
- W2034731698 hasConceptScore W2034731698C2776694085 @default.
- W2034731698 hasConceptScore W2034731698C2776858809 @default.
- W2034731698 hasConceptScore W2034731698C2777910003 @default.
- W2034731698 hasConceptScore W2034731698C2778050828 @default.
- W2034731698 hasConceptScore W2034731698C2779321679 @default.
- W2034731698 hasConceptScore W2034731698C2779554091 @default.
- W2034731698 hasConceptScore W2034731698C2780026642 @default.
- W2034731698 hasConceptScore W2034731698C2780456651 @default.
- W2034731698 hasConceptScore W2034731698C43617362 @default.
- W2034731698 hasConceptScore W2034731698C552990157 @default.
- W2034731698 hasConceptScore W2034731698C55493867 @default.
- W2034731698 hasConceptScore W2034731698C71924100 @default.
- W2034731698 hasIssue "1" @default.
- W2034731698 hasLocation W20347316981 @default.
- W2034731698 hasLocation W20347316982 @default.
- W2034731698 hasOpenAccess W2034731698 @default.
- W2034731698 hasPrimaryLocation W20347316981 @default.
- W2034731698 hasRelatedWork W146076361 @default.
- W2034731698 hasRelatedWork W182763857 @default.
- W2034731698 hasRelatedWork W1981559468 @default.
- W2034731698 hasRelatedWork W2010211804 @default.
- W2034731698 hasRelatedWork W2031646259 @default.
- W2034731698 hasRelatedWork W2071573344 @default.
- W2034731698 hasRelatedWork W2083809031 @default.
- W2034731698 hasRelatedWork W2162637812 @default.
- W2034731698 hasRelatedWork W2402840686 @default.
- W2034731698 hasRelatedWork W3037328051 @default.
- W2034731698 hasVolume "758" @default.
- W2034731698 isParatext "false" @default.
- W2034731698 isRetracted "false" @default.
- W2034731698 magId "2034731698" @default.
- W2034731698 workType "article" @default.