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- W2034732034 abstract "Glucagon and tGLP-1 receptors can be either coexpressed or selectively expressed in beta-cell models. Our results indicate that both these peptides can regulate insulin secretion from beta-cells through their own specific receptors. The finding of a selective expression of G proteins in insulin and glucagon cells indicates a clear difference in their transduction pathways. A key role of the G alpha s family in beta-cell function is further supported by its conserved cell distribution between different species. In conclusion, one could postulate that in the human beta-cells, tGLP-1 and glucagon receptors could mediate their action through different G protein alpha-subunits of the G alpha s family." @default.
- W2034732034 created "2016-06-24" @default.
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- W2034732034 date "2006-12-17" @default.
- W2034732034 modified "2023-10-01" @default.
- W2034732034 title "Pancreatic β-Cell Receptors and G Proteins Coupled to Adenylyl Cyclase" @default.
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- W2034732034 doi "https://doi.org/10.1111/j.1749-6632.1996.tb17478.x" @default.
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