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- W2034737891 abstract "The transport of proteins across the epithelial cells of small intestine is increased after rotavirus infection but it remains unaltered in secretory diarrhea. In addition, the cell turnover is increased in rotavirus but not in secretory diarrhea. The protein uptake and processing was therefore compared in villus and crypt cells isolated from the small intestine of healthy adult mice. In each fraction, lysosomal cathepsin activities and cell binding, uptake and degradation of Horseradish peroxidase (HRP) were measured. The following results were observed : (1) mice showed a decreasing gradient of cathepsins B and D from crypts to villi following the gradient of thymidine kinase, the reverse was observed for sucrase activity. (2) Binding, and internalization of HRP was twofold increased in crypt cells compared to villus cells indicating a double rate of endocytosis (binding : 12.4 ± 1.7 versus 20.3 ± 3.4 ng/mgP and internalization 60.0 ± 11.2 versus 142.8 ± 29.1 ng/mgP for intact HRP in villus and crypt cells respectively). (3) The percentage of degraded HRP into the cell remained similar in both cell types suggesting that the lysosomal degradation was not the limiting step of endocytosis. Chloroquine and ammonia but not monensin increased intracellular intact-HRP. These results suggest that intestinal villus and crypt cells do not transport proteins at the same rate. This may have important immunological consequences in pathological states in which the crypt/villus ratio is greatly increased." @default.
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- W2034737891 date "1988-09-01" @default.
- W2034737891 modified "2023-09-26" @default.
- W2034737891 title "55 PROTEIN ENDOCYTOSIS AND PROCESSING BY VILLUS AND CRYPT CELLS OF THE MOUSE SMALL INTESTINE" @default.
- W2034737891 doi "https://doi.org/10.1203/00006450-198809000-00078" @default.
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